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Other Reagent

Recombinant Human Basic Fibroblast Growth Factor (rh-bFGF)

Category:

Other Reagent

CAS NO:

62031-54-3

Standard:

In-house Standards,

Price Range:

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Main Sales Markets:

North America,Central/South America,Western Europe,Eastern Europe,Australasia,Asia,Middle East,Africa

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Zhuhai Gene-Biocon Biological Technology Co., Ltd.

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Show Room

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Basic Info

CAS Number

62031-54-3

Pharmacopoeia

In-house Standards

Grade

Pharmaceutical Grade

Is Manufacturer

YES

Packaging & Delivery

Packaging Specification

10mg/Vial 100mg/Vial

Product Description

APPLICATION

Dispensing Serum-free medium for cell culture;
Trauma repair drugs production.

FEATURES

Expression in Recombinant E. Coli.
Specific activity ≥ 1.0×107 U/mg protein.

AI Product Description

*The following content is generated by AI and is for reference only.

Recombinant Human Basic Fibroblast Growth Factor (rh-bFGF), scientifically designated as FGF2, is a potent mitogen and angiogenic factor widely utilized in biomedical research and regenerative medicine. While it does not possess a simple small-molecule molecular formula due to its proteinaceous nature, it consists of 154 amino acids with an approximate molecular weight of 17.5 kDa. The substance is typically cataloged under CAS Number 109683-84-3 for the recombinant form produced in bacterial or mammalian expression systems. The primary function of rh-bFGF involves stimulating cell proliferation, differentiation, and survival, particularly in fibroblasts, endothelial cells, and neural progenitors. It plays a critical role in wound healing by promoting angiogenesis, which facilitates the formation of new blood vessels necessary for tissue repair. In laboratory settings, rh-bFGF is an indispensable component of culture media for maintaining human embryonic stem cells and induced pluripotent stem cells in an undifferentiated state. Its ability to enhance extracellular matrix production makes it valuable for studying tissue engineering applications, including skin regeneration and cartilage repair. Furthermore, rh-bFGF has attracted significant attention in clinical trials for treating chronic ulcers, such as diabetic foot ulcers, where impaired healing is a major concern. By accelerating the migration and proliferation of keratinocytes and fibroblasts, it significantly reduces healing time. However, its application requires precise dosing and delivery methods, as uncontrolled administration can lead to adverse effects like excessive granulation or potential tumorigenic risks in specific contexts. The protein is generally supplied as a lyophilized powder containing stabilizers like bovine serum albumin to ensure long-term stability and biological activity upon reconstitution. Researchers must handle this reagent with care, adhering to strict storage conditions at -20°C or lower to prevent degradation. Overall, rh-bFGF remains a cornerstone molecule in understanding cellular dynamics and developing advanced therapeutic strategies for tissue regeneration and disease treatment.