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Preclinical Research Services
CAS NO:
90098-04-7
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Basic Info
CAS Number
90098-04-7
Pharmacopoeia
ChP
Grade
In-house Standards
Is Manufacturer
YES
Packaging & Delivery
Minimum Order Quantity
Any
Delivery Cycle
Negotiable
Product Description
Reference Standards &Impurity
AI Product Description
*The following content is generated by AI and is for reference only.
Rebamipide is a gastroprotective agent widely utilized in the treatment of various gastric disorders, particularly acute and chronic gastritis, as well as gastric ulcers. Chemically known as 4-ethyl-1,2-dihydro-3-hydroxy-6-methoxy-2-oxo-9H-quinolinyl 3-(4-chlorophenyl)propanoate, its molecular formula is C20H20ClNO5. The substance is identified by the CAS number 87378-48-5. This medication functions primarily by enhancing the mucosal defense mechanisms of the stomach lining rather than merely suppressing acid secretion. Upon administration, Rebamipide promotes the synthesis and secretion of endogenous prostaglandins, which are crucial for maintaining gastric mucosal integrity. Furthermore, it stimulates the production of mucus and bicarbonate, creating a protective barrier against aggressive factors like hydrochloric acid and pepsin. A distinctive feature of this drug is its ability to scavenge free radicals, thereby reducing oxidative stress and inflammation within the gastrointestinal tract. It also accelerates the healing process of existing ulcers by improving blood flow to the mucosa and stimulating cell proliferation. Clinically, Rebamipide is often prescribed as an adjunct therapy alongside proton pump inhibitors or antibiotics for Helicobacter pylori eradication regimens. Its favorable safety profile allows for long-term use with minimal adverse effects, making it a preferred choice in many Asian markets, especially Japan and China. Unlike some traditional anti-ulcer drugs, it does not typically cause significant systemic side effects such as dry mouth or constipation. By addressing both the underlying pathology and the symptoms, Rebamipide offers a comprehensive approach to managing digestive ailments. Its mechanism ensures that the natural repair processes of the stomach are supported, leading to sustained remission of symptoms. Consequently, it remains a cornerstone in modern gastroenterology for restoring and preserving the health of the gastric mucosa effectively.
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