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Other Specialized Reagents

Pyridine-3-sulfonyl chloride

Category:

Other Specialized Reagents

CAS NO:

16133-25-8

Standard:

In-house Standards,

Price Range:

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Main Sales Markets:

North America,Central/South America,Western Europe,Eastern Europe,Asia

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Capot Chemical Co., Ltd.

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Show Room

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Basic Info

CAS Number

16133-25-8

Pharmacopoeia

In-house Standards

Grade

pharmaceutical grade

Is Manufacturer

YES

Packaging & Delivery

Packaging Specification

1kg、5kg、25kg

Product Description

Pyridine-3-sulfonyl chloride、16133-25-8

AI Product Description

*The following content is generated by AI and is for reference only.

Pyridine-3-sulfonyl chloride, chemically identified as 3-pyridinesulfonyl chloride, is a highly reactive heterocyclic acylating agent widely utilized in organic synthesis and medicinal chemistry. With the molecular formula C₆H₄ClNO₂S and a CAS registry number of 1072-68-4, this compound serves as a crucial building block for constructing diverse sulfonyl-containing heterocycles. The molecule features a pyridine ring substituted with a chlorine atom at the third position, attached to a sulfonyl chloride functional group, which imparts significant electrophilic character to the sulfur center. The primary application of Pyridine-3-sulfonyl chloride lies in its ability to react efficiently with nucleophiles such as amines, alcohols, and thiols under mild conditions. This reactivity makes it indispensable for synthesizing sulfonamides, sulfonates, and sulfonothioates, which are key structural motifs found in numerous pharmaceutical agents, agrochemicals, and functional materials. Specifically, it is frequently employed in the development of kinase inhibitors, antibacterial drugs, and anti-inflammatory compounds where the pyridine-sulfonamide linkage confers specific biological activity and metabolic stability. Furthermore, researchers utilize this reagent to introduce solubility-modifying groups or to create linkers in drug conjugation strategies. Due to its moisture sensitivity, the compound must be handled with care under anhydrous conditions to prevent hydrolysis into the corresponding sulfonic acid. It is typically stored in a cool, dry environment away from strong bases and oxidizing agents. In industrial settings, high-purity batches are essential for ensuring consistent reaction yields in large-scale production processes. Beyond pharmaceuticals, this chemical finds niche applications in material science for modifying polymer surfaces or creating specialized dyes. Its versatility stems from the unique electronic properties of the pyridine ring, which can influence the reactivity of the resulting derivatives. As a versatile intermediate, Pyridine-3-sulfonyl chloride remains a staple reagent in laboratory research and commercial chemical manufacturing, facilitating the rapid assembly of complex molecular architectures required for modern scientific advancement.