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CAS NO:
58-33-3
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ChP,
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Basic Info
CAS Number
58-33-3
Pharmacopoeia
ChP
Grade
In-house Standards
Is Manufacturer
YES
Packaging & Delivery
Minimum Order Quantity
Any
Delivery Cycle
Negotiable
Product Description
Reference Standards &Impurity
AI Product Description
*The following content is generated by AI and is for reference only.
Promethazine Hydrochloride is a widely utilized pharmaceutical agent belonging to the phenothiazine class of drugs. Its chemical identity is defined by the molecular formula C17H20ClN3S and it is universally recognized by the CAS number 60-87-7. This compound appears as a white to slightly yellowish, crystalline powder that is highly soluble in water, facilitating its formulation into various dosage forms such as tablets, syrups, injectables, and suppositories.
The primary mechanism of action involves the antagonism of histamine H1 receptors, which makes it a potent first-generation antihistamine. Beyond its antiallergic properties, Promethazine Hydrochloride exhibits significant sedative, antiemetic, and anticholinergic effects. It acts on the central nervous system to suppress nausea and vomiting, often used for motion sickness, postoperative recovery, or chemotherapy-induced emesis. Additionally, its strong sedative qualities make it effective for managing anxiety, insomnia, and as a pre-anesthetic medication to reduce secretions and induce calmness. Clinically, it is also employed to treat allergic reactions, including urticaria and rhinitis, though its use is sometimes limited due to potential side effects like drowsiness and dry mouth.
Safety considerations are paramount when administering this drug. It carries warnings regarding respiratory depression, particularly in children under two years of age, where it is contraindicated due to the risk of fatal breathing difficulties. Extrapyramidal symptoms, such as dystonia or akathisia, may occur with high doses or prolonged use. Despite these risks, Promethazine Hydrochloride remains a cornerstone in emergency medicine and outpatient care for symptom management. Its versatility allows it to be combined with other analgesics for enhanced pain relief or used alone for severe allergic responses. Continuous medical supervision ensures its safe application, balancing therapeutic benefits against adverse reactions to optimize patient outcomes across diverse clinical scenarios.
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