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Other Specialized Reagents

Procaine hydrochloride

Category:

Other Specialized Reagents

CAS NO:

51-05-8

Standard:

In-house Standards,

Price Range:

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Main Sales Markets:

North America,Central/South America,Western Europe,Eastern Europe,Australasia,Asia,Middle East,Africa

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Jinan Jianfeng Chemical Co., Ltd.

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Basic Info

CAS Number

51-05-8

Pharmacopoeia

In-house Standards

Grade

Pharmaceutical Grade

Is Manufacturer

YES

Product Description

Chemical Properties	Small, colorless crystals or white, crys- talline powder; odorless; stable in air. Soluble in water and in alcohol at 25C; slightly soluble in chloroform; almost insoluble in ether; solutions acid to litmus.
Uses	Local anesthesic;Na+ channel blocker

AI Product Description

*The following content is generated by AI and is for reference only.

Procaine hydrochloride, commonly known as Novocain, is a synthetic local anesthetic and vasodilator widely utilized in medical and dental practices. Its chemical identity is defined by the molecular formula C13H21ClN2O2, with a corresponding CAS Registry Number of 51-05-8. This white, crystalline powder is highly soluble in water and exhibits mild stability under standard storage conditions, making it suitable for various pharmaceutical formulations. Historically significant as one of the first amide-type local anesthetics to replace cocaine in clinical settings, procaine hydrochloride functions by blocking voltage-gated sodium channels on neuronal membranes. By inhibiting the influx of sodium ions, it prevents the generation and propagation of action potentials, effectively numbing specific areas of the body without inducing unconsciousness. The drug is primarily administered via injection for infiltration anesthesia, nerve blocks, and spinal anesthesia, offering rapid onset but relatively short duration of action compared to newer agents like lidocaine or bupivacaine. Due to its short half-life, it is often preferred for minor surgical procedures where prolonged numbness is unnecessary. Beyond its primary role in pain management, procaine hydrochloride has been investigated for potential therapeutic applications in treating alcohol dependence and certain neurological disorders, although these uses remain largely experimental or adjunctive. It serves as a crucial intermediate in organic synthesis for producing other derivatives and is sometimes used in research to study membrane physiology. While modern medicine has largely transitioned to longer-acting anesthetics with fewer allergic reactions, procaine remains valuable in specific scenarios due to its unique metabolic profile and safety record when used correctly. Patients with known hypersensitivity to ester-type anesthetics must avoid this compound. Proper handling requires adherence to strict dosage guidelines to prevent systemic toxicity, which can manifest as central nervous system depression or cardiovascular collapse. Overall, procaine hydrochloride stands as a foundational agent in the history of pharmacology, bridging early anesthetic development with contemporary pain management strategies while maintaining a distinct niche in specialized medical applications.