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CAS NO:
148553-50-8
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Basic Info
CAS Number
148553-50-8
Pharmacopoeia
ChP
Grade
In-house Standards
Is Manufacturer
YES
Packaging & Delivery
Minimum Order Quantity
Any
Delivery Cycle
Negotiable
Product Description
Reference Standards &Impurity
AI Product Description
*The following content is generated by AI and is for reference only.
Pregabalin, widely recognized by its brand name Lyrica among others, is a potent pharmaceutical agent belonging to the class of gabapentinoids. Its chemical identity is defined by the molecular formula C8H17NO2 and it carries the unique CAS registry number 148553-50-8. Structurally, it serves as an analog of gamma-aminobutyric acid (GABA), yet unlike GABA itself, it does not bind directly to GABA receptors. Instead, Pregabalin exerts its therapeutic effects by binding with high affinity to the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system. This specific interaction significantly reduces the influx of calcium ions into nerve terminals, thereby decreasing the release of several excitatory neurotransmitters, including glutamate, norepinephrine, and substance P.
Clinically, Pregabalin is primarily indicated for the management of neuropathic pain associated with diabetic peripheral neuropathy, postherpetic neuralgia, and spinal cord injury. Furthermore, it has gained widespread approval for the treatment of fibromyalgia and is frequently utilized as an adjunctive therapy for partial-onset seizures in patients with epilepsy. Beyond these core indications, off-label applications often include generalized anxiety disorder and certain mood stabilization protocols. The drug demonstrates rapid absorption and linear pharmacokinetics, allowing for flexible dosing schedules that typically begin at lower levels and titrate upward based on patient response and tolerability. Common side effects may include dizziness, somnolence, dry mouth, and peripheral edema, necessitating careful monitoring during initial treatment phases. While highly effective for neurological conditions characterized by hyperexcitability, Pregabalin requires strict medical supervision due to its potential for misuse and dependence in some populations. Its mechanism of action offers a distinct advantage over traditional anticonvulsants or opioids, providing significant relief for chronic pain syndromes where other treatments have failed, making it a cornerstone medication in modern neurology and pain management practices globally.
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