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<h3>Overview</h3>
<p><strong>Polymyxin B sulfate</strong> (CAS: 1405-20-5) is a cationic polypeptide antibiotic produced via fermentation of <em>Bacillus polymyxa</em>. It functions by disrupting bacterial cell membranes. The molecular formula is typically represented as a complex mixture with the sulfate salt form.</p>
<h3>Application</h3>
<ul>
<li><strong>Pharmaceuticals:</strong> Treatment of multidrug-resistant Gram-negative infections.</li>
<li><strong>Research:</strong> Endotoxin removal in protein purification processes.</li>
<li><strong>Topical Formulations:</strong> Ophthalmic and otic preparations for local infection control.</li>
</ul>
<h3>Precautions</h3>
<p>Strictly limited to hospital settings due to nephrotoxicity and neurotoxicity risks. Store under refrigerated conditions (< 8°C) in dry, light-protected environments to maintain stability.</p>