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Basic Info
Pharmacopoeia
In-house Standards
Grade
Food Grade
Is Manufacturer
YES
Product Description
What is phloretin?
Phloretin powder is a new type of natural skin whitening agent developed by new research, mainly derived from the peel and root bark of apples. As a functional cosmetic raw material, it has attracted extensive attention from researchers in the beauty industry. It is also a flavonoid compound with dihydrochalcone structure, which has antioxidant, anti-inflammatory, whitening, sunscreen, antibacterial, moisturizing and other functions, and has been used in cosmetics.
Product Details Form
| CAS | 60-82-2 |
| MF | C15H14O5 |
| MW | 274.27 |
| EINECS | 200-488-7 |
| Melting point | ~260°C |
| Boiling point | 337.26°C (roughestimate) |
| Density | 1.1827 (roughestimate) |
| FEMA | 4390 |
| Refractive index | 1.573-1.575 |
| Acidity coefficient (pKa) | 7.16±0.40 (Predicted) |
| Solubility | Soluble in methanol, ethanol and acetone |
| MDL number | MFCD00002288 |
| PubChem number | 24278652 |
| BRN number | 1887240 |
What are the benefits for the skin?
1. Antioxidant, Anti Free Radical
Phloretin powder has strong antioxidant properties, has an antioxidant effect on oils, and can scavenge free radicals in the skin.
2. Whitening Spots
Its whitening mechanism is mainly to inhibit the activity of tyrosinase in the body, thereby reducing the production of melanin in the body.
3. Promote Transdermal Absorption
is a lipophilic compound that penetrates into the skin via intercellular lipids
4. Anti-Inflammatory Activity
Regarding anti-inflammatory experiments, in vitro studies have shown that it can inhibit the production of inflammatory factors, chemokines and differentiation factors
5. Sunscreen
It has a certain UV absorption capacity, and it can be added to the basic formula of cosmetics to improve the SPF and SPA value of cosmetics.
6. Antibacterial Activity
is a flavonoid compound with antibacterial activity
7. Moisturizing Effect
The 4 hydroxyl groups contained in the molecule can form hydrogen bonds with water molecules, absorb water, and have potential moisturizing effects. Therefore, it can also be used as a natural moisturizing agent in moisturizing cosmetics.
8. Anti-Hair Loss Effect
Studies have shown that it can inhibit the activity of soybean lipoxygenase, thereby reducing the loss of hair due to premature aging.
Product Usage & Recommended Dosage
|
Specification |
Recommended dose |
|
Phloretin 98% |
0.3%-2.0% |
Phloretin powder is widely used in masks, lotions, essences, creams, sunscreens, shampoos, conditioners and other types of cosmetics and care products.
Cosmetic
It is widely used in the field of cosmetics for its whitening, moisturizing and other effects
Health products
Antioxidant, free radical scavenging, anti-inflammatory and immunosuppressive effects
Flavor, spice
1. Inhibit bitterness and other unpleasant tastes in food and improve taste
2. Reduce the odor of high-intensity sweeteners and mask undesired flavors
3. Use with stevia as a taste modifier
Process flow
Studies on Phloretin and Cosmetics:
|
Pilot projects |
Concentration |
Effect description |
|
Elimination of free radical DPPH |
32umol/L |
Elimination rate: 74.6% |
|
Inhibition of lipid peroxidation |
13umol/L |
Inhibition rate: 53% |
|
Promotion of type 4 collagen production by phloretin in cell culture |
25ug/mL |
Promotion rate: 201.6±20.6 (blank 100) |
|
The protection of phloretin on apoptosis of stratum corneum cells under 1.0J/cm2 UVB irradiation |
400ug/mL |
Protection rate: 51.3%v9.6% |
|
The promotion of brain amide production by phloretin in cell culture |
2umol/L |
Promotion rate: 164 (blank 100) |
|
Inhibition of tyrosinase activity |
0.05% |
Inhibition rate: 82.2% |
|
Inhibition of hyaluronidase activity |
100ug/mL |
Inhibition rate: 93.5% |
|
Inhibition of 5α-reductase activity |
Half inhibitory dose IC50: 84.3ug/mL |
|
|
Inhibition of metalloprotease MMP-1 activity |
5umol/L |
Inhibition rate: 78% |
|
Inhibition of interleukin IL-4 production |
Half inhibitory dose IC50: >30umol/L |
|
|
Inhibition of β-hexosaminidase activity |
100ug/mL |
Inhibition rate: 93.5% |
|
Inhibition of transepidermal water evaporation by coating phloretin |
50umol/L |
Inhibition rate: 25% (compared with blank) |
Company introduction and certificates obtained
YTBIO mainly supplies Phloretin powder and other products. The company was established in 2014 and has many years of experience in R&D and production. We are committed to the R&D, production and sales of raw materials for the health industry in the 21st century. The certificates obtained so far include ISO9001, ISO22000, HALAL, KOSHER, HACCP, FDA etc. We always maintain the highest demands on product quality.
Our packaging
Our packing method is 1KG/Aluminium bags, 25kg/drum
For some products that require special packaging during transportation, we will carry out more delicate packaging. For example, retinal needs to be stored at -20 °C, so we choose cold chain transportation during transportation; deoxyarbutin will change color during transportation, so we will Vacuum packing of deoxyarbutin
Our team
Our team is professional, and our business team has undergone strict and professional product training. To ensure that our customers have a good cooperation experience and all questions during the cooperation process can be answered in a timely manner.
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Copyright 2006-2025 (All Rights Reserved)
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