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CAS NO:
65-28-1
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ChP,
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Basic Info
CAS Number
65-28-1
Pharmacopoeia
ChP
Grade
In-house Standards
Is Manufacturer
YES
Packaging & Delivery
Minimum Order Quantity
Any
Delivery Cycle
Negotiable
Product Description
Reference Standards &Impurity
AI Product Description
*The following content is generated by AI and is for reference only.
Phentolamine is a potent, non-selective alpha-adrenergic antagonist widely utilized in clinical and diagnostic settings. Its chemical identity is defined by the molecular formula C17H20N4O3 and it is registered under CAS number 58-68-8. Structurally, it belongs to the imidazoline class of compounds, which allows it to effectively block both alpha-1 and alpha-2 adrenergic receptors without significant selectivity between them. This unique pharmacological profile distinguishes it from newer, more selective agents like prazosin or doxazosin.
The primary therapeutic application of phentolamine is the management of hypertensive crises induced by pheochromocytoma, a rare tumor of the adrenal gland that secretes excessive catecholamines. By blocking alpha receptors on vascular smooth muscle, phentolamine induces rapid vasodilation, thereby lowering blood pressure and preventing cardiovascular collapse during surgical manipulation of such tumors. Additionally, it serves as a critical antidote for tissue necrosis caused by the extravasation of potent vasoconstrictors, such as norepinephrine or dopamine, during intravenous therapy. In these cases, local infiltration of phentolamine reverses severe vasoconstriction, restoring blood flow and preventing tissue death.
Beyond acute care, phentolamine plays a vital role in diagnostic testing. It is used in the "phentolamine test" to confirm the diagnosis of pheochromocytoma by observing the reduction in blood pressure following administration in patients with suspected high catecholamine levels. Furthermore, its ability to induce vasodilation makes it useful in treating erectile dysfunction, where it is sometimes injected directly into the corpus cavernosum to facilitate erection by increasing arterial inflow. While generally well-tolerated, common side effects include tachycardia, palpitations, hypotension, and gastrointestinal disturbances due to its systemic sympatholytic activity. Despite the availability of more selective drugs, phentolamine remains an indispensable tool in emergency medicine, endocrinology, and urology due to its rapid onset and reliable efficacy in reversing alpha-mediated vasoconstriction.
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