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CAS NO:
173174-07-7
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Basic Info
CAS Number
173174-07-7
Pharmacopoeia
ChP
Grade
In-house Standards
Is Manufacturer
YES
Packaging & Delivery
Minimum Order Quantity
Any
Delivery Cycle
Negotiable
Product Description
Reference Standards &Impurity
AI Product Description
*The following content is generated by AI and is for reference only.
Olopatadine is a highly selective second-generation antihistamine and mast cell stabilizer widely utilized in ophthalmic formulations for the treatment of allergic conjunctivitis. Its chemical identity is defined by the molecular formula C24H31N2NaO4, representing its sodium salt form, which enhances solubility and bioavailability for ocular delivery. The substance is cataloged under CAS number 107859-67-0, serving as a unique identifier for regulatory and pharmaceutical tracking globally. Structurally, it belongs to the piperazine class of compounds, featuring a complex arrangement that allows it to interact effectively with specific histamine receptors without significant central nervous system penetration, thereby minimizing sedative side effects often associated with first-generation antihistamines.
The primary therapeutic application of Olopatadine lies in managing symptoms associated with seasonal and perennial allergic conjunctivitis. It functions through a dual mechanism of action: it competitively blocks H1 histamine receptors to prevent immediate allergic responses and simultaneously inhibits the release of inflammatory mediators from mast cells, providing sustained relief. This dual activity makes it particularly effective in alleviating itching, redness, tearing, and swelling of the eyes caused by allergens such as pollen, dust mites, and pet dander. Clinically administered as eye drops, usually in concentrations of 0.1% or 0.2%, it offers rapid onset of action, often within fifteen minutes, with efficacy lasting up to eight hours, allowing for convenient twice-daily dosing.
Beyond its role in allergy management, research continues to explore potential off-label uses for other ocular surface disorders involving inflammation. The drug is generally well-tolerated, with transient stinging or mild irritation being the most common adverse events reported. Due to its safety profile and high selectivity, Olopatadine has become a standard of care in ophthalmology worldwide, preferred over older agents for its superior efficacy and lack of systemic absorption. As an active pharmaceutical ingredient, it remains a cornerstone in modern allergy therapy, significantly improving the quality of life for millions of patients suffering from chronic ocular allergies.
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