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<h3>Overview</h3>
<p><strong>Nedaplatin</strong> is a second-generation platinum-based antineoplastic agent. Its synthesis involves the reaction of ammonium tetrachloroplatinate with glycinamide to form a stable, water-soluble complex. The molecular formula is <strong>C<sub>6</sub>H<sub>14</sub>N<sub>2</sub>O<sub>4</sub>Pt</strong>, and its CAS number is <strong>95039-11-7</strong>.</p>
<h3>Application</h3>
<ul>
<li><strong>Oncology:</strong> Primary treatment for non-small cell lung cancer (NSCLC) and esophageal cancer.</li>
<li><strong>Chemotherapy Regimens:</strong> Used as monotherapy or in combination with cisplatin alternatives for patients with renal impairment.</li>
<li><strong>Gynecological Oncology:</strong> Management of recurrent cervical cancer.</li>
</ul>
<h3>Precautions</h3>
<ul>
<li><strong>Contraindications:</strong> Avoid use in patients with severe myelosuppression or hypersensitivity to platinum compounds.</li>
<li><strong>Safety:</strong> Requires strict handling protocols due to potential nephrotoxicity and ototoxicity risks.</li>
<li><strong>Storage:</strong> Store at controlled room temperature, protected from light, and ensure stability during infusion preparation.</li>
</ul>