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Preclinical Research Services
CAS NO:
767615-69-0
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ChP,
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Basic Info
CAS Number
767615-69-0
Pharmacopoeia
ChP
Grade
In-house Standards
Is Manufacturer
YES
Packaging & Delivery
Minimum Order Quantity
Any
Delivery Cycle
Negotiable
Product Description
Reference Standards &Impurity
AI Product Description
*The following content is generated by AI and is for reference only.
Naltrexone is a potent opioid antagonist primarily utilized in the management of alcohol use disorder and opioid dependence. Its chemical identity is defined by the molecular formula C20H23NO4, with the corresponding CAS Registry Number 16590-41-3. Structurally, it is a derivative of oxymorphone, specifically designed to block opioid receptors without activating them, thereby preventing the euphoric effects associated with opioid misuse.
The primary clinical application of Naltrexone involves relapse prevention. In the context of opioid addiction, it works by competitively binding to mu-opioid receptors in the central nervous system. This blockade effectively inhibits the rewarding sensations produced by exogenous opioids, making the drug less appealing to individuals recovering from substance abuse. Similarly, for alcohol use disorder, Naltrexone modulates the endogenous opioid system, which plays a significant role in the reinforcing properties of alcohol consumption. By reducing cravings and the pleasurable response to drinking, it supports long-term abstinence and recovery efforts.
Beyond its approved indications, research has explored potential therapeutic uses for other conditions involving impulse control or addictive behaviors, though these remain largely investigational. The medication is available in various formulations, including immediate-release tablets, extended-release injectable suspensions, and sublingual films, allowing for flexible treatment protocols tailored to patient needs. It is crucial that patients undergoing Naltrexone therapy are fully detoxified from opioids prior to initiation to avoid precipitating acute withdrawal symptoms. Common side effects may include nausea, headache, dizziness, and fatigue, while serious risks involve hepatotoxicity at high doses or severe allergic reactions. As an essential component of comprehensive addiction treatment programs, Naltrexone serves as a vital pharmacological tool to restore functionality and improve quality of life for individuals struggling with dependency disorders.
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