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<h3>Overview</h3>
<p><strong>Sodium hexamethyldisilazane</strong> (CAS 13596-40-8) is a potent silylating agent and strong non-nucleophilic base. Synthesized via the reaction of sodium metal with hexamethyldisilazane, its molecular formula is C<sub>6</sub>H<sub>18</sub>N<sub>2</sub>Na.</p>
<h3>Application</h3>
<ul>
<li><strong>Organic Synthesis:</strong> Deprotonation of weak acids and generation of silyl enol ethers.</li>
<li><strong>Pharmaceuticals:</strong> Intermediate production for active pharmaceutical ingredients requiring precise deprotection.</li>
<li><strong>Materials Science:</strong> Surface modification of inorganic fillers to improve polymer compatibility.</li>
</ul>
<h3>Precautions</h3>
<p>Strictly store under inert atmosphere due to moisture sensitivity. Requires PPE against corrosive burns; incompatible with water and protic solvents generating flammable gases.</p>