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CAS NO:
71980-98-8
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ChP,
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Basic Info
CAS Number
71980-98-8
Pharmacopoeia
ChP
Grade
In-house Standards
Is Manufacturer
YES
Packaging & Delivery
Minimum Order Quantity
Any
Delivery Cycle
Negotiable
Product Description
Reference Standards &Impurity
AI Product Description
*The following content is generated by AI and is for reference only.
Mupirocin, also known as pseudomonic acid A, is a potent topical antibiotic widely utilized in clinical settings for treating bacterial skin infections. Its molecular formula is C36H64O13, and it carries the CAS registry number 12650-79-8. This unique compound was originally isolated from the bacterium *Pseudomonas fluorescens* and functions by specifically inhibiting bacterial protein synthesis. It achieves this by binding irreversibly to isoleucyl-tRNA synthetase, an essential enzyme required for amino acid incorporation during translation. Because of its high specificity, Mupirocin exhibits minimal cross-resistance with other antibiotic classes and demonstrates excellent activity against Gram-positive organisms, particularly methicillin-resistant *Staphylococcus aureus* (MRSA) and *Streptococcus pyogenes*.
The primary application of Mupirocin is the treatment of impetigo, a highly contagious superficial skin infection, as well as secondary infected dermatoses. It is frequently prescribed as a first-line therapy for nasal decolonization of MRSA carriers to prevent surgical site infections and hospital-acquired outbreaks. Available commercially under brand names such as Bactroban, it is formulated into ointments, creams, and nasal ointments. The ointment base often contains polyethylene glycol, which enhances penetration through the stratum corneum but may cause irritation in some patients with compromised skin barriers. Unlike many systemic antibiotics, Mupirocin has negligible systemic absorption when applied topically, significantly reducing the risk of adverse drug interactions or systemic toxicity.
Despite its efficacy, resistance mechanisms have emerged, primarily through mutations in the target enzyme or the acquisition of plasmid-mediated resistance genes like *mupA*. Consequently, prudent stewardship is recommended to preserve its utility. In summary, Mupirocin remains a cornerstone in dermatological antimicrobial therapy, offering a safe and effective solution for localized Gram-positive infections while playing a critical role in infection control protocols within healthcare facilities worldwide.
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