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CAS NO:
51596-11-3
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ChP,
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Basic Info
CAS Number
51596-11-3
Pharmacopoeia
ChP
Grade
In-house Standards
Is Manufacturer
YES
Packaging & Delivery
Minimum Order Quantity
Any
Delivery Cycle
Negotiable
Product Description
Reference Standards &Impurity
AI Product Description
*The following content is generated by AI and is for reference only.
Milbemycin Oxime is a broad-spectrum macrocyclic lactone antiparasitic agent widely utilized in veterinary medicine to control and prevent various internal and external parasitic infections. Chemically classified within the milbemycin family, this compound acts by binding to glutamate-gated chloride channels in the nerve and muscle cells of susceptible parasites. This interaction increases membrane permeability to chloride ions, leading to hyperpolarization, paralysis, and eventual death of the parasite. The molecular formula for Milbemycin Oxime is C32H46N2O9, and it is identified by the CAS registry number 80161-54-2. Its unique mechanism of action distinguishes it from older anthelmintics, providing high efficacy against nematodes while maintaining a favorable safety profile for companion animals.
The primary applications of Milbemycin Oxime focus on heartworm prevention and treatment of intestinal parasites in dogs and cats. It is highly effective against Dirofilaria immitis (heartworm) microfilariae and adult stages when used as part of a comprehensive prevention program. Furthermore, it controls common gastrointestinal nematodes such as hookworms (Ancylostoma caninum, Ancylostoma tubaeforme), roundworms (Toxocara canis, Toxascaris leonina), and whipworms (Trichuris vulpis). In feline patients, it effectively treats Ancylostoma tubaeforme and Toxocara cati. Due to its potency at low doses, it is frequently formulated into monthly chewable tablets or topical solutions, often combined with other active ingredients like praziquantel to cover tapeworms as well.
Safety is a critical consideration; while generally well-tolerated in most breeds, specific genetic mutations in Collie-type dogs may cause neurological sensitivity due to P-glycoprotein transporter deficiencies. Consequently, screening or caution is advised for affected breeds. Despite these rare exceptions, Milbemycin Oxime remains a cornerstone in modern parasitology, offering pet owners a convenient, reliable solution to protect their animals from debilitating diseases transmitted by fleas, ticks, and worms. Its continued use underscores its importance in maintaining animal health and preventing zoonotic transmission risks associated with common helminths.
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