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Basic Info
Is Manufacturer
No
Samples Provided
NO
Packaging & Delivery
Packaging Specification
25kg/drum
Product Description
Metronidazole benzoate. Metronidazole benzoate is a benzoate ester resulting from the formal condensation of benzoic acid with the hydroxy group of metronidazole. It has a role as an antibacterial drug, an antimicrobial agent, an antiparasitic agent, an antitrichomonal drug and a prodrug. It derives from a metronidazole and a benzoic acid.
AI Product Description
*The following content is generated by AI and is for reference only.
Metronidazole Benzoate is a synthetic nitroimidazole derivative widely recognized in pharmaceutical science as a potent antimicrobial and antiprotozoal agent. Chemically, it serves as the benzoic acid ester of metronidazole, designed to enhance stability and modify release profiles compared to its parent compound. Its molecular formula is C13H16N4O3, and it carries the unique Chemical Abstracts Service (CAS) registry number 29758-03-6. The molecule features a distinctive structure comprising an imidazole ring substituted with a hydroxyethyl group and a benzoate moiety, which contributes significantly to its physicochemical properties and biological activity.
The primary clinical application of Metronidazole Benzoate lies in the treatment of infections caused by anaerobic bacteria and various protozoan parasites. It is particularly effective against Trichomonas vaginalis, responsible for trichomoniasis, as well as Entamoeba histolytica, which causes amoebic dysentery and liver abscesses. Furthermore, it plays a crucial role in managing bacterial vaginosis and is often utilized in combination therapies for Helicobacter pylori eradication. Beyond human medicine, this compound finds utility in veterinary practice for treating similar gastrointestinal and reproductive tract infections in animals, ensuring broader therapeutic coverage across species.
Mechanistically, Metronidazole Benzoate acts by penetrating microbial cells and undergoing reduction within the cytoplasm. This process generates toxic free radicals that damage DNA, leading to strand breakage and ultimately cell death. Unlike many other antibiotics, it exhibits minimal impact on aerobic organisms, making it highly selective for anaerobic pathogens. As a prodrug, the benzoate ester facilitates better absorption and bioavailability before enzymatic hydrolysis releases the active metronidazole form at the site of infection. While generally well-tolerated, patients must be monitored for potential side effects such as metallic taste, nausea, or neurological symptoms during prolonged therapy. Due to its efficacy and specificity, Metronidazole Benzoate remains a cornerstone in modern anti-infective pharmacotherapy, continuing to save lives through its reliable action against stubborn anaerobic and parasitic diseases globally.
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