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CAS NO:
364-62-5
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Basic Info
CAS Number
364-62-5
Pharmacopoeia
ChP
Grade
In-house Standards
Is Manufacturer
YES
Packaging & Delivery
Minimum Order Quantity
Any
Delivery Cycle
Negotiable
Product Description
Reference Standards &Impurity
AI Product Description
*The following content is generated by AI and is for reference only.
Metoclopramide is a widely utilized pharmaceutical agent belonging to the class of dopamine receptor antagonists and serotonin 5-HT3 receptor antagonists. With the Chemical Abstracts Service (CAS) registry number 364-62-5, its molecular formula is C14H22ClN3O2. Structurally, it consists of a chlorobenzamide moiety linked to an imidazolidinone ring, which facilitates its unique pharmacological profile. This compound acts primarily by blocking dopamine D2 receptors in the chemoreceptor trigger zone of the central nervous system while simultaneously enhancing acetylcholine release in the gastrointestinal tract.
The primary clinical application of Metoclopramide involves the management of gastroesophageal reflux disease (GERD), diabetic gastroparesis, and postoperative nausea and vomiting. By accelerating gastric emptying and increasing lower esophageal sphincter tone, it effectively alleviates symptoms such as heartburn, bloating, and early satiety associated with delayed gastric motility. Furthermore, it serves as a potent antiemetic for patients undergoing chemotherapy or surgery, providing relief from severe nausea and vomiting that often accompanies these medical interventions.
Despite its therapeutic efficacy, the use of Metoclopramide requires careful monitoring due to potential adverse effects. The most significant concern is the risk of extrapyramidal symptoms, including tardive dyskinesia, particularly with long-term usage or high doses. Other side effects may include drowsiness, restlessness, fatigue, and diarrhea. Consequently, regulatory agencies generally recommend limiting treatment duration to no more than twelve weeks to minimize neurological risks. It is contraindicated in patients with gastrointestinal obstruction, hemorrhage, or pheochromocytoma. While effective for short-term symptom control, clinicians must weigh benefits against risks, ensuring appropriate patient selection and dosage adjustment based on renal function and individual response. As a generic medication, it remains an accessible and cost-effective option for managing various gastrointestinal disorders worldwide, though ongoing research continues to explore safer alternatives for chronic management.
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