| CAS:188447-91-8 MF: C7H9NOS |
Chemical properties of (S)-(+)- p - methyl benzene sulfonamide
Melting point: 118-121 ° C (lit.)
Boiling point: 0 ° C
Flash: 0 ° C
Optical rotation (optical activity) : [alpha] 22 / D + 85 °, c = 1 in chloroform
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<h3>Overview</h3>
<p>(S)-(+)-p-Toluenesulfinamide (CAS <strong>188447-91-8</strong>) is a chiral auxiliary defined by its sulfinamide group. The molecular formula is C<sub>7</sub>H<sub>9</sub>NO<sub>2</sub>S. It serves as a critical intermediate in asymmetric synthesis, enabling the stereoselective construction of complex pharmaceutical scaffolds.</p>
<h3>Application</h3>
<ul>
<li><strong>Pharmaceutical Synthesis:</strong> Acts as a chiral pool reagent for constructing enantiopure amines and amides.</li>
<li><strong>Agrochemicals:</strong> Utilized in developing specific herbicides requiring precise stereochemistry.</li>
<li><strong>Research:</strong> Employed in academic studies for mechanism exploration in organocatalysis.</li>
</ul>
<h3>Precautions</h3>
<p>Store under inert atmosphere at 2-8°C to prevent racemization. Use appropriate PPE including gloves and eye protection; avoid inhalation of dust. Not approved for direct clinical use as an active ingredient.</p>