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Other Specialized Reagents

Methyl 4-chloro-4-oxobutyrate

Category:

Other Specialized Reagents

CAS NO:

1490-25-1

Standard:

In-house Standards,

Price Range:

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Main Sales Markets:

North America,Central/South America,Western Europe,Eastern Europe,Asia

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Capot Chemical Co., Ltd.

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Basic Info

CAS Number

1490-25-1

Pharmacopoeia

In-house Standards

Grade

pharmaceutical grade

Is Manufacturer

YES

Packaging & Delivery

Packaging Specification

1kg、5kg、25kg

Product Description

Methyl 4-chloro-4-oxobutyrate、1490-25-1

AI Product Description

*The following content is generated by AI and is for reference only.

Methyl 4-chloro-4-oxobutyrate, chemically known as methyl 4-chloro-3-oxobutanoate in some contexts but strictly defined here as the ester of 4-chlorosuccinic acid mono-methyl ester with a ketone functionality, is a valuable intermediate in organic synthesis. Its molecular formula is C5H7ClO3, and it carries the CAS Registry Number 106-29-2. This compound features a reactive chloro-ketone moiety attached to a methyl ester group, making it highly versatile for various chemical transformations. The presence of both an electrophilic carbonyl carbon and a leaving chloride atom allows it to participate in nucleophilic substitution, condensation, and cyclization reactions with high efficiency. In the pharmaceutical industry, Methyl 4-chloro-4-oxobutyrate serves as a critical building block for synthesizing heterocyclic compounds, particularly pyrazoles, pyridines, and other nitrogen-containing rings that form the core structures of many bioactive drugs. It is frequently utilized in the preparation of non-steroidal anti-inflammatory drugs (NSAIDs) and cardiovascular agents where specific ring systems are required for therapeutic efficacy. Additionally, this reagent finds applications in agrochemical research, aiding in the development of novel pesticides and herbicides that target specific enzymatic pathways in plants or pests. From a synthetic methodology perspective, the compound acts as an excellent acylating agent or a precursor for constructing complex carbon skeletons. Its stability under standard storage conditions, provided it is kept away from moisture and strong bases, ensures reliable performance in laboratory and industrial settings. Researchers often employ it in multi-step synthesis sequences to introduce functional groups that enhance solubility or biological activity. While handling requires standard safety precautions due to its potential irritant properties and reactivity, its cost-effectiveness and availability make it a preferred choice for process chemists. Overall, Methyl 4-chloro-4-oxobutyrate remains an indispensable tool in modern medicinal chemistry and fine chemical manufacturing, bridging simple starting materials with sophisticated active pharmaceutical ingredients through precise structural modifications.