Orange yellow crystalline powder; the product hardly dissolves in water, ethanol, chloroform or diethyl ether, and it easily dissolves in dilute alkali, and it can dissolve in dilute hydrochloric acid.
*The following content is generated by AI and is for reference only.
<h3>Overview</h3>
<p><strong>Methotrexate</strong> is a folate antagonist synthesized via condensation of 2,4-diamino-6-hydroxypyrimidine with benzoylglutamic acid. Its molecular formula is <strong>C<sub>20</sub>H<sub>22</sub>N<sub>8</sub>O<sub>5</sub></strong> and CAS number is <strong>59-05-2</strong>.</p>
<h3>Application</h3>
<ul>
<li>Chemotherapy for acute lymphoblastic leukemia and osteosarcoma.</li>
<li>Treatment of rheumatoid arthritis as an immunomodulator.</li>
<li>Management of psoriasis in moderate to severe cases.</li>
</ul>
<h3>Precautions</h3>
<p>Strictly monitor renal function and bone marrow suppression. Store below 25°C in dry conditions away from light to maintain stability.</p>