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CAS NO:
59-33-6
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ChP,
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Basic Info
CAS Number
59-33-6
Pharmacopoeia
ChP
Grade
In-house Standards
Is Manufacturer
YES
Packaging & Delivery
Minimum Order Quantity
Any
Delivery Cycle
Negotiable
Product Description
Reference Standards &Impurity
AI Product Description
*The following content is generated by AI and is for reference only.
Mepyramine, chemically known as pyrilamine maleate, is a widely recognized first-generation antihistamine belonging to the ethanolamine class. Its molecular formula is C17H21N3O4, and it carries the CAS registry number 1065-48-9 for its free base form, while the commercially prevalent maleate salt version is identified by CAS 138-32-9. This compound functions primarily as a selective H1-receptor antagonist, effectively blocking the action of histamine at peripheral sites within the human body. By inhibiting these receptors, Mepyramine alleviates the symptoms associated with allergic reactions, including urticaria (hives), rhinitis, conjunctivitis, and various cutaneous pruritus conditions.
Beyond its primary indication for allergy management, Mepyramine exhibits significant sedative properties due to its ability to cross the blood-brain barrier, which distinguishes it from second-generation non-sedating antihistamines. Consequently, it is frequently utilized in over-the-counter formulations for the temporary relief of cold and flu symptoms, often combined with other agents like paracetamol or codeine to address coughs and nasal congestion. The drug also finds application in the treatment of motion sickness and as an adjunctive therapy in severe acute allergic responses, such as insect bites or stings, where rapid symptom control is critical.
Administration typically occurs via oral tablets, capsules, or liquid suspensions, though injectable forms are available for emergency settings requiring immediate intervention. While generally well-tolerated, common side effects include drowsiness, dry mouth, blurred vision, and urinary retention, necessitating caution when operating heavy machinery or driving. Despite the availability of newer, less sedating alternatives, Mepyramine remains a cornerstone in pharmacotherapy for acute allergic episodes due to its rapid onset of action, high efficacy, and cost-effectiveness. It continues to be a vital component in global medical formularies, serving both clinical practitioners and patients seeking reliable relief from hypersensitivity disorders.
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