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Is Manufacturer
YES
Product Description
About The Detailed Introduction Of Mangiferin?
Mangiferin (mangiferin), also known as Guan Zhi Mu Ning, is a carbon ketone glycoside of tetrahydroxypyrrole, which belongs to the flavonoid compound of bisphenopyrone, mainly derived from the dry rhizome of the perennial herb Anemarrhena anemarrhena, plant almond , mango leaves, fruits, bark, roots of the genus Salacia in the genus Salacia of the vine family, etc.; it has the functions of relieving cough, relieving asthma, eliminating phlegm, immune, anti-inflammatory and analgesic, protecting liver and gallbladder, and anti-lipid overload. Oxidative, anti-diabetic, antibacterial, antiviral and other pharmacological activities, the current clinical applications mainly include mango cough tablets, mango cough capsules, mangiferin tablets, mangiferin dripping pills, and these agents are limited to respiratory diseases.
Properties: Melting point 267～272℃ (decomposition). Optical rotation +43.3° (c=0.9, pyridine), 32° (ethanol). Slightly soluble in methanol, ethanol, water, soluble in hot dilute methanol, hot dilute ethanol, insoluble in non-polar solvents.
Plant Sources: present in the fruits, leaves, and bark of Mango (Mangifera indica L.), rhizome and aerial parts of Liliaceae (Anemarrhena asphodeloides Bge.), and stems of Iris (Belamcanda chinensis (L. ) DC.] flowers, leaves and other plants.
Product Details List
| CAS | 4773-96-0 |
| Molecular formula | C19H18O11 |
| Molecular weight | 422.34 |
| EINECS | 624-757-7 |
| Melting point | 267～272℃ |
| Boiling point | 842.66 ℃ |
| Water solubility | slightly soluble |
| Density | 1.843 g/cm³ |
| Flash point | 303.58 ℃ |
What Are The Benefits?
Anti-Oxidize Effect
Due to the special structure of mangiferin, there are many phenolic hydroxyl groups in the molecule, and the phenolic hydroxyl groups happen to be important groups for scavenging free radicals and active oxygen. Its mechanism of action on free radicals can be attributed to two aspects: on the one hand, it directly acts on scavenging free radicals; on the other hand, it acts on iron and copper ions to reduce their further reaction with free radicals.
Neuroprotection
Mangiferin with polyphenol structure can protect neurons by reducing the cell death caused by glutamate in neurons by weakening Ca2+ influx and oxidative stress.
Antiviral Effect
It has anti-herpes simplex virus type I (HSV-I) effect in vitro, and the plaque reduction rate is 56.8%. Its antiviral effect is attributed to its ability to inhibit virus replication in cells.
The antipyretic effect has a good antipyretic effect on the experimental animal model of fever caused by endotoxin, and is positively correlated with the dose, and has a good protective effect on thermal injury.
Analgesic Effect
It has a significant analgesic effect on the pain induced by acetic acid and hot plate test. By comparing with naloxone hydrochloride, it is found that the analgesia induced by mangiferin is not dependent on opioid receptors. Its analgesic effect is significant and has no effect on peripheral nerves. slight. Anti-Parasitic Effect
Mangiferin has obvious inhibitory effect on Cryptosporidium parvum in young mice. Effects of mangiferin on mice infected with the nematode, Trichinella spiralis.
Antidiabetic Effect
After oral administration of mangiferin and its glucoside, the blood sugar level of normal mice did not change, but it could reduce the blood sugar concentration of the spontaneous diabetic animal model KK-Ay mice, and the serum insulin level also tended to decrease. Fruit glycosides and their glucosides may exhibit antidiabetic activity through insulin sensitization.
Liver And Choleretic Effect
For the protection of the liver, mangiferin can stabilize the lysosomal membrane and directly inhibit the activity of lysosomal acid phosphatase. Mangiferin also has obvious choleretic effect.
Effects On The Central Nervous System
Mangiferin has obvious excitatory effects on the central nervous system. Mangiferin has the function of removing lipid peroxide in brain tissue, reducing the damage of lipid peroxide to neurons, thereby protecting the normal function of neurons.
Effect On The Respiratory System
It has anti-inflammatory effect like adrenal glucocorticoid, can reduce capillary permeability, and its anti-inflammatory response rate reaches 38%. Due to the anti-inflammatory effect of mangiferin, it has a certain effect on bronchial asthma, as shown in ① it can significantly prolong the induction time compared with the asthma group; ② it can reduce the degree of asthma, and the incidence of convulsions is significantly lower than that of the asthma group; The inflammatory cell infiltration in the lungs was significantly less than that of the asthma group, and the lung/body weight ratio was significantly lower than that of the asthma group and close to that of the dexamethasone group. At the same time, mangiferin can reduce the level of serum NO and endothelin-1 (ET-1) in alveolar lavage fluid, and has a certain preventive effect on asthma attacks. The combination of mangiferin and dexamethasone can improve the efficacy.
Respiratory System
Mangiferin can significantly prolong the latent period of wheezing induced by histamine and acetylcholine in guinea pigs; induced cough by concentrated ammonia water in mice can significantly prolong the latent period of cough induced by mice, and significantly reduce the number of coughs in mice; It can significantly inhibit the increase of permeability; it can obviously promote the excretion of phenol red in mouse trachea.
Cardiovascular
Mangiferin at a dose of 1-2mg has a short-term and definite effect on enhancing myocardial contractility in normal or poorly functioning isolated Ringcrs solution perfused frog hearts, and this effect is not blocked by propranolol, so it may It is a direct cardiac stimulant.
Antiviral
Mangiferin has anti-herpes simplex virus type Ⅰ (HSV-Ⅰ) effect in vitro, and the plaque reduction rate is 56.8%. Its antiviral effect is attributed to its ability to inhibit virus replication in cells.
Anti-Radiation
Mangiferin is a natural antioxidant for scavenging free radicals and a natural radioprotectant. The 4 phenolic hydroxyl groups in its molecular structure have electrophilic ability, and the benzene ring is a good energy trap, so it can make biological Molecules undergo a certain transfer of free radicals induced by irradiation, thereby protecting biomolecules.
Antidiabetic
After oral administration of mangiferin and its glucoside, the blood sugar level of normal mice did not change, but it could reduce the blood sugar concentration of the spontaneous diabetic animal model KK-Ay mice, and the serum insulin level also tended to decrease.
Intraperitoneal injection of mangiferin can significantly reduce the amount of glycosylated hemoglobin and serum creatine phosphokinase (CPK) caused by oxidative damage in diabetic rats.
Protect Liver And Gallbladder
In the in vitro incubation experiment of rat liver lysosomes, it was found that mangiferin can stabilize the lysosomal membrane and directly inhibit the activity of lysosomal acid phosphatase
Other Information
Mangiferin still has antibacterial; anti-inflammatory; antipyretic and immune regulation effects. The pharmacological effects of mangiferin are clear; there are a wide range of plant sources, and it is mainly used clinically for respiratory diseases. Although mangiferin is greatly limited in clinical application due to poor solubility and other reasons, its anti-cancer; anti-virus and anti- Diabetes and other activities have attracted more and more people's attention. It is believed that with the deepening of research, mangiferin will have a good development prospect.
Extraction Method
1. Organic solvent extraction
The process uses more than 90% ethanol as the extraction solvent, and high-purity mangiferin can be extracted from mango leaves.
2. Water-based solvent extraction
The process uses weak alkaline water as the extraction solvent to extract mangiferin from mango leaves, and the extract is eluted by D101 column macroporous resin and D301 column to remove impurities and decolorize. This high-purity mangiferin extraction process is suitable for large-scale industrial production.
3. Enzymatic extraction process
Using cellulase to extract mangiferin from mango leaves by enzymatic hydrolysis, the experimental conditions: enzymatic hydrolysis pH 5.0, temperature 55°C, time 2h.
4. Ultrasonic-assisted extraction process
The ultrasonic-assisted extraction process has the advantages of simplicity, short time consumption, energy saving, etc., and has a good development and application prospect.
What Are The Application Directions?
Pharmaceutical Preparations: It has various pharmacological effects such as anti-oxidation, anti-inflammation, anti-bacterial, and anti-tumor. Therefore, it is often used in the preparation of pharmaceutical preparations for the treatment of inflammatory diseases, tumors, cardiovascular diseases, liver diseases, etc. Mangiferin can be used to prepare pharmaceutical forms such as oral liquids, capsules, and injections.
Medical And Health Products: Mangiferin powder is often made into medical and health products, such as health food, dietary supplements, etc. Due to its antioxidant, anti-inflammatory and immunomodulatory effects, mangiferin can enhance the body's immunity, improve antioxidant capacity, prevent chronic diseases, etc. It is often used in products that enhance physical health, anti-aging, and boost immunity.
Food Additive: It can be used as a food additive and is widely used in food processing. It has good anti-oxidation properties, can prolong the fresh-keeping period of food, and reduce the negative impact of oxidation reaction on food. Mangiferin can be added to various foods such as fruit and vegetable juices, beverages, dairy products, pastries, frozen foods, etc., to provide additional health and nutritional benefits.
Cosmetics: Due to its antioxidant and anti-inflammatory effects, it is often added to cosmetics. It can help reduce skin inflammation, soothe sensitive skin, improve skin texture, lighten dark spots, smooth fine lines and more. Mangiferin is widely used in skin care products such as creams, lotions, masks, shampoos, etc., to provide moisturizing and repairing effects for the skin.
Daily Chemicals: It can also be used in the field of daily chemicals. For example, it can be added to toothpaste to help prevent oral inflammation and inhibit bacterial growth; it can also be added to shampoo and body wash to moisturize, repair and soothe the scalp.
Company Introduction And Certificates Obtained
Shaanxi Yuantai Biological Technology Co., Ltd (YTBIO) was established in 2014, mainly supplying herbal extracts, functional cosmetic raw materials, organic products, etc. We have our own factories, R&D and quality inspection teams, and have the conditions for development, production, and quality assurance. At present, we have obtained ISO9001, ISO22000, HALAL, KOSHER, HACCP, FDA, and other certificates. Therefore, the quality of our products is guaranteed, and it is our original intention to bring high-quality products to customers.
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