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<h3>Overview</h3>
<p>Letrozole is a non-steroidal aromatase inhibitor synthesized via <strong>cyanation</strong> and cyclization. Its molecular formula is C17H11N5, with CAS number 112809-51-5.</p>
<h3>Application</h3>
<ul>
<li><strong>Oncology:</strong> First-line treatment for hormone receptor-positive advanced breast cancer in postmenopausal women.</li>
<li><strong>Fertility:</strong> Off-label use to induce ovulation in anovulatory infertility cases.</li>
<li><strong>Research:</strong> Tool compound for studying estrogen-dependent pathways.</li>
</ul>
<h3>Precautions</h3>
<p>Contraindicated in pregnancy due to fetal toxicity. Store in a cool, dry place below 25°C under inert atmosphere. Personnel must utilize PPE including nitrile gloves and respirators during handling.</p>