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CAS NO:
84057-84-1
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Basic Info
CAS Number
84057-84-1
Pharmacopoeia
ChP
Grade
In-house Standards
Is Manufacturer
YES
Packaging & Delivery
Minimum Order Quantity
Any
Delivery Cycle
Negotiable
Product Description
Reference Standards &Impurity
AI Product Description
*The following content is generated by AI and is for reference only.
Lamotrigine, chemically known as 6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine, is a widely prescribed antiepileptic drug (AED) and mood stabilizer used primarily in the management of epilepsy and bipolar disorder. Its molecular formula is C9H7Cl2N5O, with a precise CAS registry number of 84057-84-1. This compound functions as a voltage-gated sodium channel blocker, effectively inhibiting the release of excitatory neurotransmitters like glutamate and aspartate from presynaptic neurons. By stabilizing neuronal membranes and reducing abnormal electrical activity in the brain, Lamotrigine prevents the initiation and propagation of seizures.
In clinical practice, it serves as a first-line treatment for partial-onset seizures and generalized tonic-clonic seizures in patients aged two years and older. Furthermore, it is highly valued in psychiatry for its efficacy in maintenance treatment of bipolar I disorder, particularly for preventing depressive episodes. Unlike many other mood stabilizers, Lamotrigine offers a favorable side-effect profile regarding weight gain and cognitive impairment, making it a preferred choice for long-term therapy. It is available in various formulations, including immediate-release tablets, orally disintegrating tablets, and chewable dispersible tablets, allowing for flexible dosing strategies tailored to individual patient needs.
However, the administration of Lamotrigine requires careful titration to minimize the risk of serious dermatological reactions, such as Stevens-Johnson syndrome or toxic epidermal necrolysis, which are rare but potentially life-threatening. Consequently, healthcare providers strictly follow gradual dose escalation protocols, especially when initiating therapy or reintroducing the drug after an interruption. While generally well-tolerated, common adverse effects may include dizziness, headache, nausea, and insomnia. As a generic medication, Lamotrigine remains an essential component of modern neurology and psychiatry, offering significant therapeutic benefits for millions of patients worldwide struggling with seizure disorders and mood instability. Its mechanism of action and safety profile continue to make it a cornerstone in the pharmacological management of these chronic conditions.
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