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Active Pharmaceutical Ingredients

L-Glutathione Powder

Category:

Active Pharmaceutical Ingredients

CAS NO:

Standard:

In-house Standards,

Price Range:

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Main Sales Markets:

North America,Central/South America,Western Europe,Eastern Europe,Australasia,Asia,Middle East,Africa

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Shaanxi Yuantai Biological Technology Co., Ltd

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Basic Info

CAS Number

Pharmacopoeia

In-house Standards

Grade

pharmaceutical grade

Is Manufacturer

YES

Samples Provided

Product Description

L-Glutathione powder (GSH) is a tripeptide consisting of glutamic acid, cysteine and glycine, and contains sulfhydryl groups. Glutathione (GSH) has antioxidant and integrated detoxification effects. The sulfhydryl group on cysteine is the glutathione active group (hence the glutathione is often referred to as g-SH), which is easy to combine with some drugs (such as paracetamol) and toxins (such as free radicals, iodoacetic acid, mustard gas, lead, , arsenic and other heavy metals), and thus has integrated detoxification effect. Thus, glutathione (especially glutathione in hepatocytes) is involved in biotransformation, which converts harmful toxins into harmless substances and excrete them out of the body. Glutathione also helps maintain normal immune system function

We have ten years of experience in the field of plant extracts and cosmetic raw materials. We have our own factory, and for our cooperation to be more convenient and fast, we have set up branches in Europe and the United States, which can deliver faster and more favorable s price

As a glutathione powder supplier（glutathione wholesale supplier）, we supply pure glutathione powder (glutathione reduced powder). Regarding l glutathione powder, we can supply all products in the glutathione series. If you need wholesale glutathione, our initial cooperation may start with bulk glutathione , and all of our products support third-party testing.

Test Report

ITEM	STANDARD	TEST RESULT
L-Glutathione	98.0%~101.0%	99.31%
Physical & Chemical
Appearance	White crystalline powder	Complies
Solubility	Soluble in water	Complies
Appearance of solution	Clear and colorless	Complies
Loss on Drying	≤0.5%	0.41%
Optical rotation	-15.5~-17.5°	-16.5°
Sulfate	≤0.03%	Complies
Chloride	≤0.02%	Complies
Ammonium(NH4)	≤ 0.02%	Complies
Total Related Substances	≤2.0%	1.4%
GSSG	≤1.5%	0.4%
Ash	≤0.1%	0.06%
Heavy Metal
Total Heavy Metals	≤10ppm	Complies
As	≤2ppm	Complies
Pb	≤2ppm	Complies
Microbiological Test
Total Plate Count	≤1,000cfu/g	<100cfu/g
Mold and Yeast	≤100cfu/g	<10cfu/g
E.Coli	≤10cfu/g	<0.3cfu/g
Salmonella	Negative	Negative
Staphylococcus	Negative	Negative
Conclusion	Conform with specification
Storage	Store in cool and dry places. Keep away from strong light and heat.
Packing	By 25kgs/Drum, inner by double plastic bag
Shelf Life	24 months under the above condition,and in it’s original package

Flow Chart

L-Glutathione Flow Chart

Analysis Report

Glutathione Analysis Report

Determination Of Content

1.1 Instrument And Equipment

High Performance Liquid Chromatography (HPLC)

Chromatographic Work Station (N2010)

1.2 The Condition Of Instrument

Chromatographic Column: Ｃ18 150×4.6ｍｍ+ Guard Column

Column Temperature: 29.8℃

Flow Velocity: 0.8ml/min

Detection Wavelength: 214nm

Sample Amount: 20ul

1.3 Reagent And Solution

Trifluoroacetic Acid (TFA)

Acetonitrile(CH3CN)

Buffer Solution A: 0.1% TFA，H2O

Buffer Solution B: 0.1%TFA，CH3CN

Mobile Phase C: A:B=95∶5 (volume ratio)

1.4 Test Methods

Sample and reference material of Glutathione Reduced Accurately weigh 0.25g

(accurate to 0.0002g) , add buffer A and dilute to 1000ml volumetric flask, and

perform liquid chromatography analysis within half an hour.

1.5 The Results Calculated

The content X1 (expressed in weight percent) is calculated according to formula (1)

Glutathione

In the formula,

A1—Sample absorption peak area，uv×s；

A2—reference material absorption peak area，uv×s；

m1—Weigh the sample in grams，g；

m2—Weigh the reference material in grams，g；

X2—Loss On Drying of sample，percentage by weight（%）

Molecular Structure

Glutathione

Product Function

Participate in redox reactions: as an important reducing agent, participate in a variety of redox reactions in the body

Protect the activity of sulfhydrylase: keep the active group of sulfhydrylase—SH in a reduced state

Maintain the stability of the red blood cell membrane structure: eliminate the damaging effect of oxidants on the red blood cell membrane structure

As an important antioxidant in the body, glutathione can remove free radicals in the body

L-Glutathione powder whitening skin: inhibit melanin

Adding glutathione to food can play an unexpected role:

1. Adding to noodle products can play a reducing role. It not only shortens the time for making bread to one-half or one-third of the original, but also greatly improves the working conditions, and plays a role in strengthening food nutrition and other functions.

2. Add it to yogurt and baby food, which is equivalent to vitamin C, which can act as a stabilizer

3. Mix it into the fish cake to prevent the color from deepening.

4. Adding to meat products and cheese and other foods has the effect of intensifying flavor

The whitening mechanism of glutathione:

Reduced l glutathione powder can reduce tyrosinase activity in three different ways. Tyrosinase is directly inhibited by sulfhydryl chelating copper sites. Secondly, glutathione interferes with the cell transfer of tyrosinase to premelanosomes, which is a prerequisite for melanin synthesis. Third, the inhibition of tyrosinase is achieved indirectly through its antioxidant effect. Glutathione transfers melanogenesis from eumelanin to pheomelanin synthesis through the reaction between sulfhydryl and dopaquinone, resulting in the formation of sulfhydryl-dopa conjugates. Glutathione has a strong antioxidant capacity and has been proven to eliminate the reactive oxygen species produced in epidermal cells induced by ultraviolet radiation.