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Preclinical Research Services
CAS NO:
542-05-2&752922-26-2
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Basic Info
CAS Number
542-05-2&752922-26-2
Pharmacopoeia
ChP
Grade
In-house Standards
Is Manufacturer
YES
Packaging & Delivery
Minimum Order Quantity
Any
Delivery Cycle
Negotiable
Product Description
Reference Standards &Impurity
AI Product Description
*The following content is generated by AI and is for reference only.
Ketoglutaric acid, scientifically known as 2-oxoglutaric acid or alpha-ketoglutarate (AKG), is a pivotal intermediate in the tricarboxylic acid (TCA) cycle, also known as the Krebs cycle. With the molecular formula C5H6O5 and CAS number 328-50-7, this organic dicarboxylic acid plays a fundamental role in cellular energy production and metabolic regulation. Naturally occurring in all living organisms, it serves as a critical link between carbohydrate, fat, and protein metabolism by facilitating the conversion of amino acids into usable energy sources.
In industrial and pharmaceutical applications, Ketoglutaric acid is highly valued for its versatility. It is widely utilized as a precursor in the synthesis of various pharmaceutical compounds, including antibiotics and cardiovascular drugs. Furthermore, it acts as a key reagent in biochemical research for studying enzyme kinetics, particularly those involving dehydrogenases and transaminases. The compound is essential in cell culture media, where it supports cell growth and viability by maintaining optimal metabolic flux within mammalian cells.
Beyond its biological significance, AKG has gained attention in the nutraceutical industry due to its potential anti-aging and performance-enhancing properties. Research suggests that supplementation may improve muscle recovery, reduce fatigue, and support immune function by modulating nitrogen balance and promoting collagen synthesis. Its ability to act as an antioxidant helps mitigate oxidative stress, making it attractive for sports nutrition and longevity supplements. Additionally, it is employed in food processing as an acidity regulator and flavor enhancer.
The compound typically appears as a white crystalline powder or colorless solution, depending on its salt form, such as calcium or magnesium ketoglutarate. While generally recognized as safe for consumption in regulated doses, professional handling is required in laboratory settings to ensure purity and stability. As global demand for metabolic health solutions grows, Ketoglutaric acid remains a cornerstone ingredient in both therapeutic interventions and functional food formulations, bridging the gap between basic biochemistry and advanced clinical applications.
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