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<h3>Overview</h3>
<p><strong>O-6-Benzylguanine</strong> (CAS: 5478-20-6) is a potent inhibitor of O6-alkylguanine-DNA alkyltransferase, widely utilized in oncology research. Synthesized via nucleophilic substitution of guanine derivatives, it features the molecular formula C10H9N5O2.</p>
<h3>Application</h3>
<ul>
<li>Cancer therapy enhancement by sensitizing tumors to alkylating agents.</li>
<li>Pharmacological studies on DNA repair mechanisms and resistance pathways.</li>
<li>Development of targeted chemotherapy protocols for glioblastoma.</li>
</ul>
<h3>Precautions</h3>
<p>Store under inert atmosphere at -20°C. Handle with appropriate PPE; avoid inhalation or skin contact. Clinical use requires strict regulatory compliance due to potential toxicity profiles.</p>