*The following content is generated by AI and is for reference only.
<h3>Overview</h3>
<p>J&K 6-Maleimidohexanoic acid N-hydroxysuccinimide ester is a bifunctional crosslinker used to conjugate maleimide groups with sulfhydryl residues. The core process involves NHS-ester formation for efficient amine coupling. Its molecular formula is <strong>C15H18N2O5</strong> and CAS number is <strong>90049-79-1</strong>.</p>
<h3>Application</h3>
<ul>
<li><strong>Antibody-Drug Conjugates (ADCs):</strong> Linking cytotoxic payloads to monoclonal antibodies via cysteine residues.</li>
<li><strong>Protein Labeling:</strong> Attaching fluorescent dyes or biotin to proteins containing free thiols.</li>
<li><strong>Bioconjugation:</strong> Creating stable thioether bonds in diagnostic reagents and enzyme immobilization.</li>
</ul>
<h3>Precautions</h3>
<p>This compound is not intended for direct clinical administration. Handle in a fume hood wearing appropriate PPE due to potential irritancy. Store under inert atmosphere at -20°C to prevent hydrolysis of the reactive ester moiety.</p>