*The following content is generated by AI and is for reference only.
<h3>Overview</h3>
<p>J&K 3-(Maleimido)propionic acid N-hydroxysuccinimide ester is a high-purity crosslinking reagent used to conjugate thiol groups. Its <strong>molecular formula</strong> is C<sub>12</sub>H<sub>12</sub>N<sub>2</sub>O<sub>5</sub>, and the <strong>CAS number</strong> is 86922-24-7. This compound features an active NHS ester moiety reacting with primary amines.</p>
<h3>Application</h3>
<ul>
<li><strong>Bioconjugation:</strong> Linking antibodies to fluorophores or enzymes via maleimide-thiol chemistry.</li>
<li><strong>Drug Delivery:</strong> Synthesizing antibody-drug conjugates (ADCs) for targeted cancer therapy.</li>
<li><strong>Protein Modification:</strong> Site-specific labeling of cysteine residues in research proteins.</li>
</ul>
<h3>Precautions</h3>
<p>Store at -20°C under inert atmosphere to prevent hydrolysis. Handle with appropriate PPE as it may cause skin irritation. Not intended for direct human injection without rigorous purification and clinical validation.</p>