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1072833-77-2
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Basic Info
CAS Number
1072833-77-2
Pharmacopoeia
ChP
Grade
In-house Standards
Is Manufacturer
YES
Packaging & Delivery
Minimum Order Quantity
Any
Delivery Cycle
Negotiable
Product Description
Reference Standards &Impurity
AI Product Description
*The following content is generated by AI and is for reference only.
Ixazomib is a novel oral proteasome inhibitor developed for the treatment of multiple myeloma, a cancer of plasma cells. Its chemical identity is defined by the molecular formula C27H38N4O5 and the CAS Registry Number 1023169-77-8. Structurally, it belongs to the boronic acid dipeptide class, featuring a unique cyclic structure that allows it to bind reversibly to the chymotrypsin-like activity site of the 20S proteasome subunit. This specific inhibition prevents the degradation of ubiquitinated proteins within the cell, leading to an accumulation of toxic protein aggregates that ultimately triggers apoptosis in malignant plasma cells.
The primary clinical indication for Ixazomib is in combination with lenalidomide and dexamethasone for patients with relapsed or refractory multiple myeloma who have received at least one prior therapy. As the first oral proteasome inhibitor approved by regulatory agencies such as the FDA, it offers a significant advantage over intravenous alternatives like bortezomib by enabling convenient administration at home without the need for clinic visits. This oral bioavailability improves patient compliance and quality of life while maintaining robust efficacy in controlling disease progression. The drug exhibits high selectivity for the 20S proteasome, minimizing off-target effects compared to earlier generation agents, although common side effects may include thrombocytopenia, peripheral neuropathy, diarrhea, and rash.
Beyond its established role in hematologic malignancies, ongoing research explores its potential application in other solid tumors and autoimmune conditions where proteasome activity plays a critical pathogenic role. The development of Ixazomib marked a pivotal shift in multiple myeloma management, providing a non-invasive therapeutic option that complements existing treatment paradigms. Its mechanism of action remains central to modern oncology strategies targeting protein homeostasis, highlighting the importance of targeted therapies in precision medicine. Continued clinical investigations aim to optimize dosing schedules and expand its utility across diverse patient populations, ensuring broader access to effective cancer care.
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