*The following content is generated by AI and is for reference only.
<h3>Overview</h3>
<p><strong>Indomethacin</strong> (CAS: 53-86-1, Formula: C19H16ClNO4) is a potent non-steroidal anti-inflammatory drug (NSAID) synthesized via condensation of 4-chlorobenzenesulfonyl chloride with indole derivatives.</p>
<h3>Application</h3>
<ul>
<li>Pharmaceutical manufacturing for rheumatoid arthritis and ankylosing spondylitis treatments.</li>
<li>Pain management in acute gouty arthritis and soft tissue injuries.</li>
<li>Patent ductus arteriosus closure therapy in neonatal intensive care units.</li>
</ul>
<h3>Precautions</h3>
<p>Strictly contraindicated in patients with active peptic ulcers or severe renal impairment. Store in cool, dry conditions below 25°C to prevent degradation. Personnel must use respiratory protection during bulk handling to avoid inhalation hazards.</p>