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Hydroxypropyl-beta-cyclodextrin

Category:

Other Intermediates

CAS NO:

128446-35-5

Standard:

USP,

Price Range:

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Main Sales Markets:

North America,Central/South America,Western Europe,Eastern Europe

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Basic Info

CAS Number

128446-35-5

Pharmacopoeia

USP

Grade

injection grade

Is Manufacturer

YES

Samples Provided

Product Description

Hydroxypropyl-beta-cyclodextrin CAS 128446-35-5 is a white or white powder, odorless, slightly sweet, easily soluble in water, with good water solubility, stability and inclusion ability, and can form inclusion compounds with a variety of substances to change the physical and chemical properties of the inclusion substances. We can provide a variety of specifications of pharmaceutical raw materials, quality assurance, fast delivery, in stock.

AI Product Description

*The following content is generated by AI and is for reference only.

Hydroxypropyl-beta-cyclodextrin (HP-β-CD) is a widely utilized, water-soluble derivative of beta-cyclodextrin, characterized by its unique toroidal structure composed of seven glucose units linked by alpha-1,4-glycosidic bonds. With the Chemical Abstracts Service (CAS) number 128446-35-5 and a molecular formula approximating C42H68O35 for the base unit with varying degrees of hydroxypropylation, this compound serves as a versatile excipient in pharmaceutical, cosmetic, and food industries. The introduction of hydroxypropyl groups significantly enhances solubility in aqueous media compared to native beta-cyclodextrin while reducing potential toxicity and renal accumulation risks associated with unmodified forms. The primary function of HP-β-CD lies in its ability to form inclusion complexes with poorly water-soluble drugs. By encapsulating hydrophobic guest molecules within its central hydrophobic cavity, it dramatically improves drug bioavailability, dissolution rates, and chemical stability without altering the therapeutic efficacy of the active ingredient. This property makes it indispensable in the formulation of intravenous injectables, oral tablets, and topical preparations where solubility is a critical barrier. Beyond pharmaceuticals, it is extensively employed in the fragrance and flavor sectors to protect volatile compounds from oxidation and evaporation, ensuring prolonged shelf life and consistent sensory profiles. In the food industry, it acts as a stabilizer for vitamins and essential oils, enhancing their dispersibility in beverages and confectioneries. Furthermore, HP-β-CD is recognized for its safety profile; it exhibits low cytotoxicity and is generally regarded as safe (GRAS) by regulatory bodies like the FDA and EMA when used within specified limits. Its non-toxic nature allows for broad application in sensitive biological systems, including gene delivery vectors and tissue engineering scaffolds. As research advances, HP-β-CD continues to be a cornerstone technology for overcoming solubility challenges, facilitating the development of next-generation drug delivery systems that maximize patient compliance and therapeutic outcomes through enhanced pharmacokinetic properties.