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Hydrocortisone sodium succinate powder for Injection.
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Tianjin Sinomed Pharmaceutical Co., Ltd.
6
Years
Basic Info
Is Manufacturer
YES
Samples Provided
NO
Packaging & Delivery
Packaging Specification
50's/box
Product Description
1.Product name:Hydrocortisone sodium succinate powder for
Injection
2.Specification: 100mg
3.Package: 50's/box
4.Shelf life:36 months
5.Registration documents are available.
If you are interested in our products,please feel free to contact us.
AI Product Description
*The following content is generated by AI and is for reference only.
Hydrocortisone sodium succinate for injection is a synthetic glucocorticoid formulated as a sterile, lyophilized powder intended for intravenous or intramuscular administration. Upon reconstitution with an appropriate diluent, it serves as a potent anti-inflammatory and immunosuppressive agent widely utilized in acute clinical settings. Its primary indications include the management of severe allergic reactions, such as anaphylaxis refractory to epinephrine, and the treatment of acute exacerbations of chronic inflammatory conditions like rheumatoid arthritis or asthma. Furthermore, it plays a critical role in replacing endogenous corticosteroids in patients with adrenal insufficiency during periods of physiological stress, trauma, or surgery, preventing life-threatening adrenal crisis.
The mechanism of action involves binding to cytoplasmic glucocorticoid receptors, thereby modulating gene transcription to inhibit the synthesis of pro-inflammatory mediators like prostaglandins and leukotrienes. This rapid onset of action makes it indispensable in emergency medicine for stabilizing hemodynamic parameters in septic shock or managing cerebral edema associated with tumors. However, its use requires strict adherence to safety protocols due to significant potential adverse effects. Common side effects include hyperglycemia, fluid retention, hypertension, and electrolyte disturbances such as hypokalemia. Long-term or high-dose therapy may precipitate immunosuppression, increasing susceptibility to infections, osteoporosis, and gastrointestinal ulceration.
Contraindications include systemic fungal infections and known hypersensitivity to hydrocortisone or any component of the formulation. Caution is advised when administering to patients with uncontrolled diabetes, peptic ulcer disease, tuberculosis, or active viral infections. Tapering the dosage is essential after prolonged use to avoid withdrawal symptoms and adrenal suppression. Additionally, concomitant use with non-steroidal anti-inflammatory drugs (NSAIDs) or anticoagulants necessitates careful monitoring due to increased risks of bleeding or gastric irritation. Healthcare providers must ensure proper reconstitution techniques to maintain sterility and potency. Overall, while Hydrocortisone sodium succinate is a vital therapeutic tool for critical care and acute inflammation, its administration demands precise clinical judgment, individualized dosing, and vigilant patient monitoring to maximize benefits while mitigating serious risks.
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