Product Description
| |
| Quetiapine fumarate Chemical Properties |
| Melting point |
174-176°C |
| Fp |
9℃ |
| storage temp. |
2-8°C |
| solubility |
DMSO: >10mg/mL |
| form |
powder |
| color |
white to off-white |
AI Product Description
*The following content is generated by AI and is for reference only.
Quetiapine Hemifumarate is a widely sought-after pharmaceutical intermediate and active ingredient, currently experiencing high market demand due to its extensive application in treating various psychiatric disorders. Chemically known as 2-[2-(4-dibenzo[b,f][1,4]thiazepin-11-ylpiperidin-1-yl)ethoxy]ethanol hemifumarate, this compound features the molecular formula C21H25N3O2S·C4H4O4. Its specific CAS Registry Number is 111974-69-9, which serves as a unique identifier for regulatory compliance and supply chain tracking globally. The substance is characterized by its white to off-white crystalline powder appearance and is highly soluble in organic solvents, making it suitable for diverse formulation processes including tablets, capsules, and liquid suspensions.
The primary therapeutic utility of Quetiapine Hemifumarate lies in its role as an atypical antipsychotic agent. It acts primarily by antagonizing dopamine D2 and serotonin 5-HT2A receptors, thereby modulating neurotransmitter activity in the brain. Clinically, it is prescribed for the management of schizophrenia, bipolar disorder (both manic and depressive episodes), and as an adjunctive treatment for major depressive disorder. Additionally, it is sometimes utilized off-label for anxiety disorders and insomnia due to its sedative properties. The hemifumarate salt form offers enhanced stability and bioavailability compared to the free base, ensuring consistent drug delivery and patient safety.
In the global pharmaceutical supply chain, Hot Sales Quetiapine Hemifumarate represents a critical component for generic drug manufacturers aiming to produce cost-effective treatments. Rigorous quality control measures are essential during production to meet international pharmacopoeial standards such as USP, EP, and JP. Manufacturers focus on maintaining high purity levels to minimize impurities that could affect efficacy or safety. As mental health awareness grows worldwide, the demand for reliable sources of this compound continues to rise, driving innovation in synthesis methods and sustainable manufacturing practices. For healthcare professionals and researchers, understanding the physicochemical properties and clinical profile of Quetiapine Hemifumarate remains vital for optimizing patient care and advancing psychopharmacological research.