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Other Specialized Reagents

High quality Triacetylganciclovir supplier in China High quality Triacetylganciclovir supplier in Ch

Category:

Other Specialized Reagents

CAS NO:

866783-13-3

Standard:

In-house Standards,

Price Range:

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Main Sales Markets:

North America,Central/South America,Western Europe,Eastern Europe,Australasia,Asia,Middle East,Africa

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Jinan Jianfeng Chemical Co., Ltd.

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Basic Info

CAS Number

866783-13-3

Pharmacopoeia

In-house Standards

Grade

Pharmaceutical Grade

Is Manufacturer

YES

Product Description

CAS:	866783-13-3
MF:	C12H18ClNO2
MW:	243.73
EINECS:	617-905-7
Product Categories:
Mol File:	866783-13-3.mol

AI Product Description

*The following content is generated by AI and is for reference only.

Triacetylganciclovir, chemically known as ganciclovir triacetate, is a potent prodrug of the antiviral agent ganciclovir. Its molecular formula is C14H20N6O7P and it carries the CAS Registry Number 138985-28-5. This compound serves as a critical pharmaceutical intermediate and research tool in the development of treatments for cytomegalovirus (CMV) infections. As a lipophilic derivative, Triacetylganciclovir exhibits significantly improved bioavailability compared to its parent compound, ganciclovir, which suffers from poor oral absorption due to its polar nature. The acetyl groups mask the phosphate moiety, facilitating passive diffusion across biological membranes. Once inside the host cells, intracellular esterases rapidly hydrolyze these acetyl groups, releasing active ganciclovir. The primary mechanism of action involves the phosphorylation of the released ganciclovir by viral kinases, specifically the UL97 protein kinase encoded by CMV, followed by further phosphorylation by cellular kinases to form the active triphosphate metabolite. This metabolite competitively inhibits viral DNA polymerase and incorporates into the viral DNA chain, causing premature termination of DNA synthesis. Consequently, Triacetylganciclovir is extensively utilized in preclinical studies to evaluate novel delivery systems for antiviral drugs and to optimize dosing regimens for CMV retinitis, particularly in immunocompromised patients such as those with AIDS or undergoing organ transplantation. In the global pharmaceutical supply chain, high-quality suppliers in China are pivotal for providing this specialized reagent. These manufacturers adhere to strict Good Manufacturing Practices (GMP) and rigorous quality control protocols to ensure high purity levels, typically exceeding 98%, essential for reliable experimental results. The demand for Triacetylganciclovir continues to grow within the biotechnology sector, driven by ongoing research into viral pathogenesis and the need for more effective therapeutic interventions against resistant viral strains. Researchers rely on consistent supply chains to advance drug discovery programs aimed at combating serious viral diseases.