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CAS NO:
1310709-74-0
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Basic Info
CAS Number
1310709-74-0
Pharmacopoeia
ChP
Grade
In-house Standards
Is Manufacturer
YES
Packaging & Delivery
Minimum Order Quantity
Any
Delivery Cycle
Negotiable
Product Description
Reference Standards &Impurity
AI Product Description
*The following content is generated by AI and is for reference only.
Halometasone, chemically known as 6α-fluoro-9-chloro-11β,16α-dihydroxypregna-1,4-diene-3,20-dione, is a potent synthetic glucocorticoid widely utilized in dermatological medicine. Its molecular formula is C22H28ClFO5, and it is identified by the CAS registry number 377-99-7. This compound belongs to the class of fluorinated corticosteroids, which are engineered to possess significantly higher anti-inflammatory and antipruritic efficacy compared to non-fluorinated predecessors like hydrocortisone. The presence of the fluorine atom at the 6-alpha position and chlorine at the 9-alpha position dramatically enhances receptor binding affinity, allowing for rapid suppression of inflammatory responses even at low concentrations.
Clinically, Halometasone is primarily indicated for the topical treatment of various inflammatory and pruritic skin conditions resistant to less potent therapies. It is frequently prescribed for managing severe cases of eczema, psoriasis, lichen planus, and contact dermatitis. The drug works by inhibiting the release of inflammatory mediators such as prostaglandins and leukotrienes, thereby reducing redness, swelling, itching, and allergic reactions. Due to its high potency, it is typically formulated into creams, ointments, lotions, or foams for localized application on affected areas of the body.
However, because of its strength, medical guidelines strictly advise against prolonged use or application over large surface areas to minimize the risk of systemic absorption. Potential side effects include skin thinning (atrophy), striae, telangiectasia, and local irritation. Long-term usage may also lead to hypothalamic-pituitary-adrenal axis suppression if absorbed systemically. Consequently, Halometasone is generally reserved for short-term management of acute flare-ups under professional supervision. Patients are advised to follow dosage instructions precisely, avoiding use on the face, groin, or axillae unless specifically directed by a healthcare provider. While highly effective for controlling stubborn dermatological symptoms, its therapeutic window requires careful monitoring to balance efficacy with safety, ensuring optimal patient outcomes without compromising skin integrity.
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