*The following content is generated by AI and is for reference only.
<h3>Overview</h3>
<p>GpppG lithium salt (CAS 1467-52-9) is a synthetic nucleotide analog serving as a non-hydrolyzable GTP mimic. Its core structure features a gamma-phosphate linkage resistant to enzymatic cleavage, ensuring stability in biochemical assays. The molecular formula is C<sub>10</sub>H<sub>18</sub>N<sub>10</sub>O<sub>14</sub>P<sub>3</sub>Li<sub>3</sub>. This compound is primarily synthesized via phosphoramidite chemistry for high-purity research applications.</p>
<h3>Application</h3>
<ul>
<li><strong>RNA Synthesis:</strong> Acts as an initiation factor for in vitro transcription systems.</li>
<li><strong>Signal Transduction:</strong> Used to study G-protein coupled receptor activation mechanisms.</li>
<li><strong>Structural Biology:</strong> Stabilizes protein-RNA complexes for X-ray crystallography analysis.</li>
</ul>
<h3>Precautions</h3>
<p>Strictly limited to laboratory research; not for human therapeutic use. Store under inert atmosphere at -20°C to prevent hydrolysis. Handle with appropriate PPE due to potential irritant properties of lithium salts and phosphate intermediates.</p>