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Preclinical Research Services
CAS NO:
624-43-1
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ChP,
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Basic Info
CAS Number
624-43-1
Pharmacopoeia
ChP
Grade
In-house Standards
Is Manufacturer
YES
Packaging & Delivery
Minimum Order Quantity
Any
Delivery Cycle
Negotiable
Product Description
Reference Standards &Impurity
AI Product Description
*The following content is generated by AI and is for reference only.
Glyceryl Trinitrate, commonly known as nitroglycerin, is a potent organic compound with the molecular formula C3H5N3O9 and the CAS registry number 55-63-0. Structurally, it consists of a glycerol backbone esterified with three nitric acid groups, rendering it an oily, colorless to pale yellow liquid that is highly sensitive to shock, friction, and heat. Historically significant for its explosive properties, it was famously utilized by Alfred Nobel in the late 19th century after he stabilized it using diatomaceous earth to create dynamite, revolutionizing mining and construction industries worldwide. However, its most enduring and life-saving application today lies within the pharmaceutical sector. In medicine, Glyceryl Trinitrate serves as a critical vasodilator used primarily to treat acute angina pectoris attacks and manage heart failure. Upon administration, typically via sublingual tablets, transdermal patches, or intravenous infusion, it is metabolized to release nitric oxide. This gas relaxes smooth muscle cells in blood vessels, causing rapid dilation of coronary arteries and peripheral veins. Consequently, venous return to the heart decreases, reducing cardiac workload and oxygen demand while simultaneously improving blood flow to ischemic myocardial tissue. Its onset of action is exceptionally fast, making it the drug of choice for immediate relief of chest pain associated with coronary artery disease. Despite its therapeutic efficacy, usage requires careful monitoring due to potential side effects such as severe hypotension, reflex tachycardia, and debilitating headaches caused by cerebral vasodilation. Furthermore, tolerance can develop with continuous exposure, necessitating specific dosing schedules to maintain effectiveness. As a controlled substance in many jurisdictions due to its dual nature as both a powerful explosive and a vital medication, strict regulations govern its manufacturing, distribution, and storage. Ultimately, Glyceryl Trinitrate remains a cornerstone compound bridging industrial chemistry and cardiovascular medicine, saving countless lives through its unique ability to modulate vascular tone instantly.
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