Product Description
Reference Standards &Impurity
AI Product Description
*The following content is generated by AI and is for reference only.
Gentamicin Sulfate is a widely utilized aminoglycoside antibiotic derived from the soil bacterium *Micromonospora purpurea*. Its chemical identity is defined by the CAS number 1405-41-0, and it possesses the molecular formula C₁₈H₃₇N₅O₇·xH₂SO₄, reflecting its complex structure as a sulfate salt of gentamicin. This potent antimicrobial agent functions by irreversibly binding to the 30S ribosomal subunit of bacteria, thereby inhibiting protein synthesis and leading to cell death. It exhibits broad-spectrum activity primarily against aerobic Gram-negative organisms, including *Escherichia coli*, *Pseudomonas aeruginosa*, *Klebsiella* species, and *Proteus*, while also showing efficacy against certain Gram-positive strains like *Staphylococcus aureus*.
In clinical practice, Gentamicin Sulfate is indispensable for treating severe infections such as sepsis, pneumonia, urinary tract infections, skin infections, and intra-abdominal infections. Due to its potential nephrotoxicity and ototoxicity, dosage must be carefully monitored via therapeutic drug monitoring to ensure efficacy while minimizing adverse effects. Beyond human medicine, this compound plays a critical role in veterinary science for managing similar bacterial infections in livestock and companion animals. Furthermore, it serves as an essential reagent in biomedical research laboratories for selecting genetically modified cells expressing resistance genes or for studying bacterial protein synthesis mechanisms. The availability of various formulations, including injectable solutions, topical ointments, and eye drops, allows for versatile administration routes tailored to specific infection sites. Despite the emergence of resistant strains, Gentamicin Sulfate remains a cornerstone in empirical therapy for serious bacterial diseases, particularly when combined with beta-lactams for synergistic effects. Its stability in solid forms makes it suitable for manufacturing diverse pharmaceutical preparations globally, ensuring accessibility for both acute care settings and chronic management protocols where indicated by susceptibility testing results.