Category:
Finished Dosage
CAS NO:
1403-66-3
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Basic Info
Is Manufacturer
YES
Samples Provided
NO
Packaging & Delivery
Packaging Specification
Box of 10 x 10ampoules & Box of 10ampoules
Product Description
1.Product name: Gentamycin Injection
2.Specification: 80mg/2ml
3.Package: Box of 10 x 10ampoules & Box of 10ampoules
4.Shelf life: 36 months
5.Registration documents are available.
If you are interested in our products,please feel free to contact us
AI Product Description
*The following content is generated by AI and is for reference only.
Gentamicin Injection is a potent aminoglycoside antibiotic primarily utilized for the treatment of serious bacterial infections caused by susceptible Gram-negative organisms. It functions by binding irreversibly to the 30S ribosomal subunit of bacteria, thereby inhibiting protein synthesis and leading to rapid cell death. This medication is frequently prescribed for severe conditions such as sepsis, pneumonia, complicated urinary tract infections, intra-abdominal infections, and skin or soft tissue infections. Due to its narrow therapeutic index, it is often reserved for hospital settings where intravenous or intramuscular administration can be closely monitored.
The drug demonstrates significant efficacy against common pathogens like Pseudomonas aeruginosa, Escherichia coli, Klebsiella species, and Proteus mirabilis. While it is sometimes used alone, clinical guidelines often recommend combining Gentamicin with beta-lactam antibiotics to achieve synergistic effects against resistant strains or in cases of endocarditis. However, its use is accompanied by critical safety considerations. The most prominent risks include nephrotoxicity, which can cause acute kidney injury, and ototoxicity, potentially resulting in irreversible hearing loss or vestibular damage. These adverse effects are dose-dependent and more likely in patients with pre-existing renal impairment, the elderly, or those receiving prolonged therapy.
Concurrent use with other nephrotoxic or ototoxic drugs, such as loop diuretics or vancomycin, significantly increases these risks and requires strict avoidance or extreme caution. Therapeutic Drug Monitoring (TDM) is essential; healthcare providers must regularly measure peak and trough serum levels to ensure efficacy while minimizing toxicity. Dosage adjustments are mandatory for patients with reduced creatinine clearance. Furthermore, Gentamicin is generally contraindicated in patients with known hypersensitivity to aminoglycosides and should be used cautiously during pregnancy due to potential fetal harm. Proper hydration and monitoring of renal function throughout the treatment course are vital protocols to ensure patient safety.
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