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Products

Antibiotics and Antiviral Preparations

Gentamicin Sulfate Injection

Category:

Antibiotics and Antiviral Preparations

CAS NO:

1405-41-0

Standard:

ChP,USP,BP,

Price Range:

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Main Sales Markets:

North America,Central/South America,Western Europe,Eastern Europe,Australasia,Asia,Middle East,Africa

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CISEN PHARMACEUTICAL CO.,LTD.

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Basic Info

Is Manufacturer

YES

Samples Provided

YES

Product Description

Gentamicin is a commonly used aminoglycoside antibiotic, which can play an antibacterial role by binding to the 30S subunit of bacterial ribosomes and blocking bacterial protein synthesis. It is mainly used to relieve the symptoms of infection caused by sensitive bacteria.

Specification： 2ml:80mg

AI Product Description

*The following content is generated by AI and is for reference only.

Gentamicin Sulfate Injection is a potent aminoglycoside antibiotic widely utilized in clinical settings to treat severe bacterial infections. It functions by inhibiting bacterial protein synthesis, thereby preventing the growth and replication of susceptible microorganisms. This medication is primarily indicated for serious infections caused by Gram-negative bacteria, including *Pseudomonas aeruginosa*, *Escherichia coli*, *Klebsiella*, *Proteus*, and *Enterobacter* species. Common clinical applications encompass septicemia, complicated intra-abdominal infections, urinary tract infections, respiratory tract infections, skin and soft tissue infections, bone and joint infections, as well as meningitis when used in combination with other agents. Due to its narrow therapeutic index, it is often reserved for cases where less toxic antibiotics are ineffective or contraindicated. Administration is strictly intravenous or deep intramuscular, requiring careful dosing based on patient weight, renal function, and serum drug levels. A critical aspect of Gentamicin therapy involves monitoring for nephrotoxicity and ototoxicity, which are its most significant adverse effects. Patients with pre-existing kidney impairment or hearing loss require dose adjustments and frequent monitoring of serum creatinine and auditory function. Additionally, neuromuscular blockade may occur, particularly in patients receiving anesthesia or those with myasthenia gravis. Concomitant use with other nephrotoxic or ototoxic drugs, such as loop diuretics or vancomycin, should be avoided unless absolutely necessary. Hypersensitivity reactions, though rare, can occur, necessitating immediate discontinuation if signs of allergy manifest. Pregnant women should generally avoid this medication due to the risk of fetal ototoxicity, although benefits may outweigh risks in life-threatening scenarios under strict medical supervision. Elderly patients are at higher risk for toxicity due to age-related decline in renal function. Therapeutic Drug Monitoring (TDM) is essential to maintain peak and trough concentrations within safe ranges, ensuring efficacy while minimizing toxicity. Proper hydration and regular laboratory assessments are vital components of successful treatment protocols. Healthcare providers must ensure that Gentamicin Sulfate Injection is used only under professional supervision to manage potential complications effectively and optimize patient outcomes in treating severe bacterial infections.