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<h3>Overview</h3>
<p>Gemcitabine (CAS <strong>95058-81-4</strong>) is a synthetic pyrimidine nucleoside analog. Its molecular formula is <strong>C<sub>9</sub>H<sub>11</sub>FN<sub>2</sub>O<sub>4</sub></strong>. The core synthesis involves fluorination of cytidine derivatives to inhibit DNA polymerase.</p>
<h3>Application</h3>
<ul>
<li><strong>Oncology Manufacturing:</strong> Active pharmaceutical ingredient for treating pancreatic, breast, and non-small cell lung cancers.</li>
<li><strong>Contract Research:</strong> Used in preclinical studies for cytotoxicity profiling.</li>
</ul>
<h3>Precautions</h3>
<p>Strictly handle as a potent cytotoxic agent requiring PPE. Store under controlled conditions (<strong>-20°C</strong>, desiccated) to maintain stability. Contraindicated in severe renal impairment without dose adjustment.</p>