
|
Product name |
Fusidic acid; Fusidine |
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CAS No. |
6990-06-3 |
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Molecular Formula |
C31H48O6 |
|
Molecular Weight |
516.719 |
|
Quality Standard |
97.5% up by HPLC |
|
Appearance |
White or almost white, crystalline powder |
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COA |
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ANALYSIS |
SPECIFICATION |
RESULTS |
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Appearance |
White or almost white, crystalline powder |
White crystalline powder |
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Solubility |
Practically insoluble in water, freely soluble in ethanol (96%) |
Practically insoluble in water, freely soluble in ethanol (96%) |
|
Identification |
IR: IR absorption spectrum of sample is in identical with that of reference substance |
IR absorption spectrum of sample is in identical with that of reference substance |
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Reaction of sodium: The residue does not give reaction (a) of sodium |
The residue does not give reaction (a) of sodium |
|
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Water |
1.4%-2.0% |
1.7% |
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Sulfated ash |
≤0.2% |
0.1% |
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Assay (on anhydrous basis) |
97.5% - 101.0% |
99.9% |
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Particle size |
90% Particle diamite < 20 μm |
100% Particle diamite < 20 μm |
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Related substance |
Impurity M ≤ 1.0% |
0.1% |
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Impurity G ≤ 0.7% |
Not detected |
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Impurity L ≤ 0.5% |
Not detected |
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Impurity B ≤ 0.4% |
Not detected |
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Impurity A ≤ 0.3% |
Not detected |
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Impurity H ≤ 0.10% |
Not detected |
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Impurity C ≤ 0.2% |
Not detected |
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Impurity D ≤ 0.2% |
Not detected |
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Impurity F ≤ 0.2% |
Not detected |
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Impurity I ≤ 0.2% |
Not detected |
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Impurity K ≤ 0.2% |
Not detected |
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Impurity K ≤ 0.2% |
Not detected |
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Max unknown impurity ≤ 0.10% |
Not detected |
|
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Total impurities ≤ 2.0% |
0.1% |
|
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Residual solvents |
Ethanol ≤ 5000pm |
Not detected |
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Methanol ≤ 3000pm |
Not detected |
|
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Ethyl acetate ≤ 5000pm |
Not detected |
|
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N-hexane ≤ 290pm |
Not detected |
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Microbial limit |
Bacteria ≤ 100cfu/g |
Not detected |
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Total molds and yeasts ≤ 10cfu/g |
Not detected |
|
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Staphylococcus aureus: None |
Not detected |
|
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Pseudomonas aeruginosa: None |
Not detected |
|
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Conclusion |
The sample complies with EP. |
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