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CAS NO:
4274-38-8
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Basic Info
CAS Number
4274-38-8
Pharmacopoeia
ChP
Grade
In-house Standards
Is Manufacturer
YES
Packaging & Delivery
Minimum Order Quantity
Any
Delivery Cycle
Negotiable
Product Description
Reference Standards &Impurity
AI Product Description
*The following content is generated by AI and is for reference only.
Fluphenazine Dihydrochloride is a potent first-generation antipsychotic medication belonging to the phenothiazine class of drugs. Chemically, it is characterized by the molecular formula C23H29FN4O4S2 and carries the CAS registry number 67-08-5. This compound serves as the dihydrochloride salt form of fluphenazine, which enhances its water solubility and stability for pharmaceutical formulation. The drug acts primarily as a high-potency dopamine D2 receptor antagonist in the central nervous system. By blocking these receptors, particularly in the mesolimbic pathway, it effectively reduces positive symptoms of psychosis, such as hallucinations, delusions, and disordered thinking associated with schizophrenia.
Due to its long half-life when administered in depot formulations, Fluphenazine Dihydrochloride is frequently utilized for maintenance therapy in patients requiring extended periods of symptom control without daily oral dosing. It is available in various forms, including immediate-release tablets and long-acting injectable suspensions. While highly effective, its clinical use requires careful monitoring due to a significant profile of extrapyramidal side effects, including tremors, rigidity, and akathisia, which are common with high-potency typical antipsychotics. Other potential adverse reactions involve anticholinergic effects like dry mouth and constipation, as well as the risk of tardive dyskinesia with prolonged use. Additionally, clinicians must be vigilant regarding neuroleptic malignant syndrome, a rare but life-threatening reaction. Despite the availability of newer atypical antipsychotics with fewer motor side effects, Fluphenazine Dihydrochloride remains a vital therapeutic option in global psychiatry, particularly in resource-limited settings or for patients who respond poorly to alternative treatments. Its robust efficacy in managing severe psychotic disorders ensures its continued relevance in modern pharmacological practice, provided that patient safety protocols are strictly adhered to during administration and dosage adjustments.
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