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CAS NO:
84378-44-9
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Basic Info
CAS Number
84378-44-9
Pharmacopoeia
ChP
Grade
In-house Standards
Is Manufacturer
YES
Packaging & Delivery
Minimum Order Quantity
Any
Delivery Cycle
Negotiable
Product Description
Reference Standards &Impurity
AI Product Description
*The following content is generated by AI and is for reference only.
Flumazenil, chemically known as ethyl 8-fluoro-5-(2-fluorophenyl)-6-oxo-6,7-dihydro-5H-benzo[1,4]diazepine-3-carboxylate, is a critical pharmaceutical agent primarily utilized in clinical settings for the reversal of benzodiazepine effects. With the CAS number 78005-98-4 and molecular formula C18H14FN3O3, this compound acts as a specific competitive antagonist at the benzodiazepine binding site on the GABA-A receptor complex. Its mechanism involves displacing benzodiazepines from their receptors without activating them, thereby rapidly reversing sedation, respiratory depression, and psychomotor impairment induced by drugs such as diazepam, midazolam, or lorazepam.
The primary indication for Flumazenil is the management of accidental overdoses involving benzodiazepines, particularly when patients present with significant central nervous system depression that requires immediate intervention. It is also employed to reverse conscious sedation following diagnostic procedures or minor surgeries where rapid recovery is desired. The drug is typically administered intravenously, allowing for a quick onset of action within one to two minutes, making it invaluable in emergency medicine and anesthesia departments. However, its use is not without risks; clinicians must exercise extreme caution in patients with chronic benzodiazepine dependence, as abrupt antagonism can precipitate severe withdrawal symptoms, including seizures. Consequently, Flumazenil is generally contraindicated in mixed overdoses involving pro-convulsant agents like tricyclic antidepressants or in patients with a history of epilepsy.
Beyond acute overdose management, Flumazenil has been investigated for potential applications in treating hepatic encephalopathy, though evidence supporting this remains less robust compared to its established role in benzodiazepine reversal. As a selective antagonist, it does not possess intrinsic anxiolytic, sedative, or anticonvulsant properties, ensuring that it only reverses the effects of co-administered benzodiazepines. Despite its narrow therapeutic window regarding seizure induction, Flumazenil remains a cornerstone medication in toxicology and perioperative care, offering a life-saving solution for reversing profound sedation while requiring careful patient selection and monitoring to ensure safety. Its unique pharmacological profile continues to make it an essential tool for medical professionals managing benzodiazepine-related complications globally.
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