Category:
Enzymes
CAS NO:
873857-62-6
Standard:
In-house Standards,
![6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one](https://eimg.pharmasources.com/image/20250617/4zoOybJjzUTk0UgguabMkX7VnrDIlxHluERwqkjK.jpg)
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Basic Info
CAS Number
873857-62-6
Pharmacopoeia
In-house Standards
Grade
Pharmaceutical Grade
Is Manufacturer
YES
Product Description
Fedamycin is a macrolide antibiotic, which has a novel mechanism of action, mainly by inhibiting the RNA polymerase of bacteria to produce rapid anti-Clostridium difficile infection (CDI). Its treatment of CDI is superior to existing drugs.
AI Product Description
*The following content is generated by AI and is for reference only.
Fidaxomicin, a macrocyclic antibiotic with the molecular formula C49H68N10O21 and CAS Registry Number 325740-28-1, represents a significant advancement in the treatment of Clostridioides difficile infection (CDI). First approved by regulatory agencies for clinical use, this drug is distinguished by its unique mechanism of action and narrow spectrum of activity. Unlike broad-spectrum antibiotics such as vancomycin or metronidazole, which disrupt the entire gut microbiome, fidaxomicin selectively targets RNA polymerase in Gram-positive bacteria, specifically inhibiting transcription initiation in C. difficile while largely sparing beneficial commensal flora. This selective pressure is crucial, as preserving the gut microbiota significantly reduces the risk of recurrent CDI, a common and often debilitating complication following initial infection.
The chemical structure of fidaxomicin features a complex macrocyclic ring linked to an aminocarbonyl side chain, contributing to its potent antibacterial properties and limited systemic absorption. Upon oral administration, the drug remains largely confined to the gastrointestinal tract, achieving high local concentrations at the site of infection with minimal entry into the bloodstream. This pharmacokinetic profile enhances safety and minimizes systemic side effects. Fidaxomicin is primarily indicated for adults with acute CDI who are not critically ill, though it is increasingly used in cases where recurrence is a major concern. Clinical trials have demonstrated that fidaxomicin leads to higher rates of sustained clinical response compared to standard therapies, effectively breaking the cycle of reinfection. Its introduction marks a paradigm shift in managing CDI, moving away from non-specific eradication toward targeted therapy that respects ecological balance within the human gut. As antibiotic resistance grows globally, fidaxomicin stands out as a vital tool for preserving both patient health and microbial diversity, offering a more sustainable approach to treating one of the most challenging hospital-acquired infections.
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