| CAS:26873-85-8 MF: (C12H22O11)n.(C3H5ClO)n |
Properties: Ficoll, white crystalline powder. Soluble in water. Stable in neutral and alkaline solutions. Hydrolysis breakdown at pH<3. Sucrose and epichlorohydrin were used as raw materials, sucrose and 3-chloro-1, 2-epichlorohydrin copolymerized to produce a synthetic water-soluble polymer, which was widely used as the medium for density gradient centrifugation. It can also be used as an inert carrier for low molecular weight haptens in immunological research.
Ficoll - 400, which has a molecular weight of 400, 000, is used to keep the osmotic pressure down, but its viscosity is particularly high, so it is often mixed with meglutamide to reduce the viscosity. It is mainly used to isolate various kinds of cells, including blood cells, fibroblasts, tumor cells, mouse liver cells, etc.
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<h3>Overview</h3>
<p>FICOLL 26873-85-8 is a high-molecular-weight <strong>polysaccharide</strong> synthesized via controlled polymerization of sucrose and epichlorohydrin. It serves as a critical density gradient medium for cell separation. Molecular formula: C<sub>n</sub>H<sub>2n+2</sub>O<sub>n+1</sub>; CAS No.: 26873-85-8.</p>
<h3>Application</h3>
<ul>
<li><strong>Diagnostics:</strong> Isolation of peripheral blood mononuclear cells (PBMCs) from whole blood.</li>
<li><strong>Biopharma:</strong> Purification of viruses and subcellular organelles in vaccine production.</li>
<li><strong>Research:</strong> Density fractionation for stem cell enrichment protocols.</li>
</ul>
<h3>Precautions</h3>
<p>Store at room temperature in sealed, dry containers to prevent microbial contamination. Avoid direct contact with eyes; use appropriate PPE during handling. Not intended for direct human injection without rigorous purification validation.</p>