*The following content is generated by AI and is for reference only.
<h3>Overview</h3>
<p>Fasudil N-Hydroxy Impurity is a critical process-related impurity found in the synthesis of Fasudil hydrochloride, a potent Rho-kinase inhibitor. This compound arises during the oxidative modification steps of the core scaffold. Its <strong>molecular formula</strong> is C10H12N2O2 and it carries <strong>CAS No. 129768-45-6</strong>, serving as an essential reference standard for quality control.</p>
<h3>Application</h3>
<ul>
<li><strong>Pharmaceutical QC:</strong> Used to validate HPLC methods for detecting trace levels in bulk drug substances.</li>
<li><strong>R&D Support:</strong> Employed in stability studies to monitor degradation pathways during formulation development.</li>
<li><strong>Regulatory Compliance:</strong> Provides data for ICH Q3A guidelines regarding impurity identification and qualification.</li>
</ul>
<h3>Precautions</h3>
<p>This substance is strictly for research use only and not approved for clinical administration. Store under inert atmosphere at 2-8°C away from light. Personnel must wear appropriate PPE including gloves and eye protection to prevent skin contact or inhalation of dust.</p>