Products

Suppliers

News

All Categories

Products or Suppliers

Content Hub

Product Zone

Sponsorship & Membership

CPHI & PMEC China

Active Pharmaceutical Ingredients

Intermediates&Fine Chemicals

Bio Products

Natural Extracts

Finished Dosage

Pharmaceutical Excipients

Pharmaceutical Outsourcing, Customised Services, and Consulting

Medical Aesthetic Skincare

Food Ingredients

API Equipment

Preparation Equipment

Pharmaceutical Packaging Machinery

TCM Machinery

Pharmaceutical water equipment

Clean Technology

Refrigeration Equipment

Parts and Components

Informatization Products

Laboratory

Packaging Materials

Measuring Instrument

Environmental Protection Equipment

Logistics

Other Consumables

Dietary Supplements‌‌

Correctives

Colorant

Filtration separation

Intelligent Logistics

Cold chain Technical &Materials

Logistics Equipment &Materials

Storage Equipment &Materials

Logistic Services

Third-party logistics

Dangerous Goods Logistics

Level instrument

Pressure gauge

Thermometers

Flow meter

Gas analysis instrument

Liquid analysis instrument

Fermenter Equipment

Other Measuring Instrument

Other Logistics

Medical Aesthetic Consumables

Sera and Vaccines

Soft tube/Hard tube

Pharmaceutical Intermediates

Anti-tumor Preparations

Pharmaceutical Manufacturing Outsourcing

Chemical and Biochemical Reactors

Mixing Equipment

CIP System(Clean in place)

Herbal medicine Concentration Equipment

Purification Equipment

Low Temperature Refrigeration

Seals

Laboratory General Equipment

Functional Food Raw Materials

Inner packaging equipment

Polluted Water / Wastewater Treatment Equipment

Injection Raw Materials and Ingredients

IVD (In Vitro Diagnostics) Consumables

Suspending Agents / Thickening Agents

Concentrator Equipment

MES System

APIs for Anti-Infective Drugs

Biochemical APIs

Botanical products

Pharma Packaging Materials

Diluents (Fillers)

Intermediates for Agrochemicals

Reagent

Cardiovascular, Cerebrovascular, and Circulatory System Formulations

Pharmaceutical R&D Outsourcing

Drying Equipment

TCM Pulverizer

Water Purification Equipment

Purification Test Instrument

Air Conditioner

‌Sanitary Fittings

Analytical Instrument

Other Dipstick Consumables

Nutraceutical Ingredients

Granules Machinery

Outer packaging

Waste Gas Treatment Equipment

Active Ingredients

Binders

Solubilizers

Drug delivery systems

Sensors

APIs for Nervous System Drugs

Animal-derived products

Endocrine and Metabolic Preparations

Disintegrants

service

Crystalling Equipment

Pill Making Equipment

Other Water Treatment Equipment

Clean Clothes/Clean Cap/Clean Shoes

Cold Storage

Pumps

Food & Beverage Raw Materials

Life Science Instrument

Tablet equipment

Other pharmaceutical packaging equipment

Solid and Hazardous Waste Treatment Equipment

Innovative Materials

Controllers & Drivers

Speciality Intermediates

Microbial products

Humectants

APIs for Digestive System Drugs

APIs for Cardiovascular System Drugs

Antibacterial and Antiviral Formulations

Lubricants

Extraction Plant

Slice Machine

Clean Bench

‌Refrigeration Auxiliaries

Valves

Biologics

TCM Raw Materials

Food Additive

Reagents and Consumables

Capsule equipment

Pharmaceutical water equipment

Testing & Monitoring Instruments and Equipment

Other Medical Aesthetics & Skincare

Veterinary Pharmaceutical Intermediates

Automation Software

APIs for Respiratory System Drugs

Bio Technology Service

Antipyretic and Analgesic Preparations

Glidants / Anti-caking Agents

Heat Exchanger

Herbal medicine Drying Equipment

Air Shower Room

Compressor

Cylinders

Fine Chemicals

Crushing equipment

Ultrapure Water System

Other Automation & Informatization Products

OEM/ODM

Measuring Instruments

Energy-saving and Low-carbon Equipment

Other Intermediates

Antiparasitic Preparations

Coating Agents

Storage Tanks, Containers

Herbal medicine Extraction Equipment

Air Purification

Other Refrigeration Equipment

Drive Equipment‌

Liquid preparation equipment

Solution Preparation System

Other Environmental Protection Equipment

APIs for Hormones and Regulatory Drugs

Other Natural Products

Physical Testing

APIs for Antiparasitic Drugs

Anti-Allergic Formulations

Plasticizer

Evaporating Equipment

TCM Cooking Equipments

Cleanroom

Reducers

Laboratory Engineering

Biopharmaceutical Equipment

Membrane Module‌

APIs for Antipyretic and Analgesic Drugs

Anti-Tuberculosis and Anti-Leprosy Formulations

Surfactant

Distillation Equipment

Drop Pill Equipment

Purifying Engineering

VFD (Variable Frequency Drive)

Other preparation equipment

Distilled water machine

Laboratory Solutions

Vitamin

Digestive System Preparations

Centrifuge

Screening Machine

Honey Pill Machine

Flooring Materials

Bearing

Emulsifiers

Ion-exchange equipment

Online Process Control

Respiratory System Preparations

Sterilizing Equipment

TCM Deposition Equipment

Spare Part‌

Other Cleaning System

Stainless Steel

Nervous System Preparations

Filter press equipment

Herbal medicine Fermentation Equipment

Plastic

‌Containment System

Special Active Ingredients

Ointment Bases

Homogenizer Equipment

Other TCM Machinery

Others Parts and Components

APIs for Veterinary Drugs and Feed Additives

Anaesthetic and Adjuvant Formulations

Air Filter

Suppository Bases

Other Active Pharmaceutical Ingredients

Blood System Formulations

Cleanroom Consumables‌

Glass lining equipment

Film-forming Agents

Urinary and Reproductive System Formulations

Other API Machinery and Equipment

Filter Paper

Release Modifiers

Immunomodulatory Formulations

Filter Paper Board

smotic Pressure Regulators / Tonicity Adjusting Agents

Water, Electrolyte, and Acid-Base Balance Regulating Formulations

Ph Control Agents

Nozzle, Tank Cleaning Machine

Vitamin, Mineral, and Amino Acid Formulations

Antioxidants / Antioxidant Synergists

Fluid Equipment

Enzyme and Other Biochemical Formulations

Antimicrobial Preservatives (Preservatives)

Tonic and Nutritional Formulations

Complexing Agents (Chelating Agents / Inclusion Compounds)

Hormonal Formulations

Dermatological Preparations

Other Preparations

Co-solvents

ENT Preparations

Penetration Enhancers (Transdermal)

Freeze-drying Protective Agents

Refrigerants / Cryogens

Capsule

Fragrances

Adsorbents

Pressure-sensitive Adhesives (PSA)

Stiffening Agents

Carriers for Dry Powder Inhalers (DPI Carriers)

Other Excipients

Pipes and Pipe Fittings

Vacuum Equipment

Air Compressor

Compressor

Other Fluid Equipment

Prefillable Syringes

Filters

Filter Presstem

Filtration System

Filter Bag

Filter Mesh

Filter Cloth

Filter Membrane

Other Filtration Equipment

Sanitary Pressure Vessel‌

Hyaluronic Acid

Collagen

Botulinum Toxin

Peptide

Other Injection Raw Materials and Ingredients

Ceramide

Ectoin

Niacinamide

Asiaticoside

Ergothioneine

Chitosan

Other Active Ingredients

Chiral Intermediates

Advanced Intermediates

Microfiltration

Ultrafiltration

Auxiliary Equipment

Separation equipment

Metered Dose Inhalers

Dry Powder Inhalers

Penicillin

Hormones

Central Nervous System Drugs

Reagents for Biopharmaceuticals

Drug Target Discovery and Validation

Plant Extracts

Animal Extracts

Synthesis/Screening

Process Development/Optimisation/Scale-Up Production

Drug Registration and Submission Services

Ointment Filling-sealing Machine、Vacuum Mixer

Eye Drug Machinery

Soft Gelatin Capsule Machinery

Tablet Press

Pneumatic Cracker

Granulator

Labelers, Label Printers

Bag Packaging Machine

Thermostatic / Heating / Drying Equipment

Chromatography

Particle Size / Particle / Powder Analysis Instruments

Tabletop

Glass bottles & Vials

Fermentation Products

Prophylactic Biological Products

Mixing Tank/Blender

Bioreactor

Intravenous Infusion Set Assembly Equipment(Pen Assembly Equipment)

PCR

Recombinant Collagen

Alkaloids

Veterinary API

Regulated Fine Chemicals

Peptides

Balances / Weighing Scales

Online Gas Chromatography

Cephalosporins

Anesthetics

Immunology Reagents

Drug Development Technologies

Pharmaceutical Chemistry

Formulation Design

Regulatory and Compliance Consulting

Syrup Machinery

Injection Medicine Machinery

Hard Capsule Filling Machine

Coating Machine

Medicine Material Grinding Machine

Lettering machine

Box Packaging Machine

Mass Spectrometry

Laboratory Bench

Aluminum Foil

Rheometers / Viscometers

‌Chemical Reagents

Cleaning & Disinfection Equipment

Granulator

Emulsifier

Biological Fermentation System

Injection Molding Equipment

Exosome

Phospholipids

Prostaglandins

Veterinary Biologics

Chemical Reagents

Therapeutic Biological Products

Biochemical Reagents

Antibodies

Natural Pigments

Animal Lipids

Enzyme Preparations

Flowmeters

Online Particle Size Analyzer

Tetracycline

Amino Acids and Derivatives

Process Optimization and Testing

Nucleic Acids and Derivatives

Pre-Clinical Research

Chemical/Biological API Manufacturing

Powder Filling Machine

Oral Liquid Machinery

Low Temperature Pulverizer

Strapping machine

Paper Film Packaging Machine

Thermal Analyzers

Spectrometers

Other Measurement and Metrology Instruments

Storage Cabinets

Plastic Bottles

Other Industrial Process Control and Online Analytical Instruments

Certification

Feed Additives

Diagnostic Biological Products

Pulverizer

Coating Machine

Capsule Filling Machine

Other Mixing Equipment

Cell Engineering Equipment

Pre-filled Syringe Production Equipment

Purification Equipment

Electrophoresis/Gel Imaging/UV Detection

Regenerative Materials

Other Fine Chemicals

Cell Biology Reagents

Biological Consumables

Feed Additives

Soft Mist Inhaler

Plant Polysaccharides

Animal Proteins

Microbial Polysaccharides

Aminoglycoside

Enzymes

Molecular Biology Reagents

Clinical Trials

Intermediate Synthesis and Production

Market and Business Strategy Consulting

Suppository Drug Machinery

Powder Injection Machinery

Pharmaceutical Milling Machinery

Printing Device

Blister Packaging Machine

Environmental Test Chambers

Moisture Analyzer

Air Discharge Equipment

Rubber Stopper

Tablet Press

Other Tablet Equipment

Capsule Production Line

Isolator

Synthesis/Reaction Equipment

Microbial Detection Instrument

Composite Biomaterials

Animal Breeding Auxiliary Products

Packaging Testing Equipment

Laboratory Glassware and General Consumables

Preclinical Research Services

Nebulizer

Essential Oils

Animal Polysaccharides

Bioactive Functional Ingredients

Macrolides

Microbial / Fermentation Reagents

Proteins

Other Technology Services

Biotechnology Services

Formulation Development and Manufacturing

Other Services

Medicine Film Drug Machinery

Infusion Medicine Machinery（中文站有输液剂机械的三级分类）

Pharmaceutical Machine Milling

Instruction Booklet Folding Machine

Fan

Chromatography Consumables and Accessories

Other Physical Properties Testing Instruments

Gasket

Sample Preparation / Digestion Equipment

X-ray Structure Analysis

Safety Cabinet

Counting Machine (Tablet)

Other Capsule Filling Equipment

Disposable Biotechnology Equipment

Vacuum Packaging Machine

Laboratory Low-temperature Storage

Other Innovative Materials

Other Veterinary

Conveying equipment

Natural Spices

Bile Acids and Active Ingredients

Sulfonamides

Other Specialized Reagents

Computational Chemistry and AI-Assisted Drug Design

Clinical Trial Drug Manufacturing

Aerosol Drug Machinery

Super Micro Mill

Bottle Conveyer

Bundling Packaging Machine

Mixing/Dispersion Equipment

Other Laboratory Complete & Ancillary Equipment

Trays

Other Laboratory Consumable

Other Preparation Machinery for Solid Medcine

‌Centrifugal Separation System

Automatic Packaging Machine

Other Analytical Instrument

Chip System/Accessories

Cytokines

Counting Machine

Cartridge Vial

Medicinal Herbs

Bee Products

Chloramphenicols

Testing

Other Pharmaceutical Manufacturing Outsourcing

Medicine Filling Machine

Disk Type Bottle Straightening Machine

Lidding Materials

Other Crushing Equipment

Ultrafiltration/Microfiltration System

Horizontal Pillow Packaging Machine

Cartoning Machine

Auto-injector

Transfection/Cell Fusion

Track & Trace

Gas Generators / Gas Handling Equipment

Blood Products

TCM Ingredients & Slices

Animal Medicinal Materials

Lincomycin

Microbial Products

Bottle Washer

Vial Sealing Machine

Liquid Handling Equipment

Hoses and Fittings

Other Biopharmaceutical Equipment

Vertical Packaging Machine

Casing Machine

Microplate Reader/Enzyme Labeling Instrument

Analysis and Validation

Serialization System

Pen Injector

Other Anti-Infective Drug

Other Pharmaceutical R&D Outsourcing

Conveyer For Medicine Material

Spray Pump

Other Injectable Equipment

Aluminum Foil Packaging Machine

Coding Machine

Cell Analysis

Automated Assembly

Other Laboratory General Equipment

Packaging Bag Valve

Freeze Dryer

Granule packaging machine

Other Drug Delivery Device Accessories

Biological Microscope/In Vivo Imaging

Other Antibiotics

Cap Screwing Machine

Nasal Drug Delivery Devices / Nasal Spray Pumps

Printing Services‌

Liquid Packaging Machine

Laboratory Automation

Screw Capping Machine

Lamp Inspection Machine

Ophthalmic Drug Delivery Devices / Eye Drop Delivery Systems

Labelling

Powder Packaging Machine

Synthesizer

Heat Shrink Packaging Machine

Metal Detector

Insulin Pens / Blood Glucose Management Devices

Security Taggants & Markings

Filter Cartridge‌

Tablet Packaging Machine

Animal Experiment Instrument

Injection & blow molding machines

Batching system

Self-Injection Systems / Safety Protection Devices

Incubator Equipment

Printed Drugs Packaging

Box filling & sealing machine

Palletizing equipment

CIP cleaning system

Topical / Gynecological / Intimate Drug Delivery Devices

Desiccants

Other Life Science Instrument

Bottle Filling Line

Contaners

Lifting Charging Machine

Others

Inhalant Packaging

BFS Bottlepack Machine

Weighting Equipment

Blister Packaging Machine

Pharmaceutical Paper

Other Pharmaceutical Outer Packaging Equipment

Packaging bag valve

Container Sealing Machine

Glass Tube

Multi-functional Bottle Packaging Machine

Medical Aesthetic Freeze-Dried Powder Vials

Sachets Cartoner Packing line

Primary Packaging

Other Pharmaceutical Inner Packaging Equipment

Aluminum Caps & Aluminum-Plastic Combination Caps

Sterile Bags / Breathing Bags / Sterilization Bags

Medical Device Packaging / Bioconsumables Packaging

Dispensing Bottles

Blister Packaging

Pharmaceutical Plastic Films / Composite Film Bags

Accessories

Ampuls

Other Packaging Materials

Products Suppliers Match & Meet

Industry Insights E-Learn Series

E-trade Season PharmaExpress

Service & Membership Contact Us

CPHI China PMEC China CPHI & PMEC Shenzhen

Home

Products

Other Specialized Reagents

Ethyl 4,4,4-trifluoroacetoacetate

Category:

Other Specialized Reagents

CAS NO:

372-31-6

Standard:

In-house Standards,

Price Range:

Get Quote

Main Sales Markets:

North America,Central/South America,Western Europe,Eastern Europe,Asia

Send inquiry

Capot Chemical Co., Ltd.

Years

Show Room

Favorites

Basic Info

CAS Number

372-31-6

Pharmacopoeia

In-house Standards

Grade

pharmaceutical grade

Is Manufacturer

YES

Packaging & Delivery

Packaging Specification

1kg、5kg、25kg

Product Description

Ethyl 4,4,4-trifluoroacetoacetate、372-31-6

AI Product Description

*The following content is generated by AI and is for reference only.

Ethyl 4,4,4-trifluoroacetoacetate is a specialized fluorinated organic compound widely utilized in the pharmaceutical and agrochemical industries as a versatile synthetic intermediate. With the chemical formula C6H7F3O3 and CAS Registry Number 2981-50-2, this colorless to pale yellow liquid possesses distinct physicochemical properties driven by its trifluoromethyl group. The presence of the highly electronegative fluorine atoms significantly alters the reactivity of the beta-keto ester structure compared to non-fluorinated analogs, enhancing acidity and stabilizing specific enolate intermediates during nucleophilic substitution reactions. This compound serves as a critical building block for the synthesis of complex heterocyclic systems, particularly pyridines, quinolones, and thiazoles. These heterocycles are foundational scaffolds in the development of modern therapeutics, including antibiotics, antiviral agents, and anti-inflammatory drugs. Furthermore, Ethyl 4,4,4-trifluoroacetoacetate plays a pivotal role in creating fluorinated agrochemicals, where it contributes to improved metabolic stability and bioavailability in crop protection products. The introduction of the CF3 group often enhances lipophilicity, allowing for better membrane permeability in biological systems, which is essential for drug efficacy. In industrial applications, the reagent is employed in multistep organic syntheses requiring precise control over stereochemistry and functional group compatibility. Its ability to undergo cyclization with various amines, hydrazines, and carbon nucleophiles makes it indispensable for constructing diverse molecular architectures. Safety protocols must be observed during handling, as with many fluorinated esters, due to potential irritancy and environmental persistence concerns. Storage should occur in cool, dry conditions away from strong oxidizers to prevent decomposition. Overall, Ethyl 4,4,4-trifluoroacetoacetate remains a high-value commodity in fine chemical manufacturing, bridging the gap between basic raw materials and advanced active pharmaceutical ingredients. Its unique combination of reactivity and stability ensures continued demand across research laboratories and large-scale production facilities seeking to innovate next-generation fluorinated compounds.