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CAS NO:
161796-78-7
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Basic Info
CAS Number
161796-78-7
Pharmacopoeia
ChP
Grade
Pharmaceutical Grade
Is Manufacturer
YES
Samples Provided
NO
Sample Policy
/
Packaging & Delivery
Packaging Specification
/
Minimum Order Quantity
/
Delivery Cycle
/
Product Description
1. Esomeprazole sodium an alternative therapy for gastroesophageal reflux disease when oral therapy is not applicable.
2. Esomeprazole sodium should usually be used for a short time (no more than 7 days), and should be converted to oral treatment whenever possible.
AI Product Description
*The following content is generated by AI and is for reference only.
Esomeprazole sodium is the S-isomer of omeprazole, a proton pump inhibitor (PPI) widely utilized in clinical practice for the treatment of acid-related gastrointestinal disorders. Its molecular formula is C17H18N3NaO4S, and it is registered under CAS number 159968-06-8. This pharmaceutical compound represents a significant advancement over its racemic predecessor, offering improved pharmacokinetic profiles due to reduced metabolic variability among patients. As a sodium salt, esomeprazole exhibits enhanced water solubility compared to the free base form, facilitating more consistent absorption and rapid onset of action when administered orally or intravenously.
The primary therapeutic application of esomeprazole sodium involves the management of gastroesophageal reflux disease (GERD), including the healing of erosive esophagitis and the maintenance of healed tissue to prevent recurrence. It is also indicated for the treatment of duodenal ulcers associated with Helicobacter pylori infection, often used in combination with antibiotics as part of a triple or quadruple therapy regimen. Furthermore, this agent plays a crucial role in preventing non-steroidal anti-inflammatory drug (NSAID)-induced gastric ulcers in high-risk populations and managing pathological hypersecretory conditions such as Zollinger-Ellison syndrome. By irreversibly inhibiting the H+/K+-ATPase enzyme system in the gastric parietal cells, esomeprazole effectively suppresses both basal and stimulated gastric acid secretion, regardless of the stimulus.
Clinically, esomeprazole sodium is available in various formulations, including delayed-release capsules, tablets, and sterile powders for injection, allowing for flexible dosing strategies tailored to patient needs. Its efficacy has been well-documented in numerous clinical trials, establishing it as a first-line therapy for severe acid reflux and ulcerative conditions. While generally well-tolerated, long-term use requires monitoring for potential side effects such as hypomagnesemia, vitamin B12 deficiency, and an increased risk of bone fractures. Overall, esomeprazole sodium remains a cornerstone medication in modern gastroenterology, providing reliable acid suppression to improve patient quality of life and facilitate the healing of mucosal damage.
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